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Bendazol Sale

(Synonyms: 地巴唑) 目录号 : GC34046

Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.

Bendazol Chemical Structure

Cas No.:621-72-7

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10mM (in 1mL DMSO)
¥354.00
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100mg
¥321.00
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500mg
¥450.00
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1g
¥707.00
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产品描述

Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.

Bendazol enhances NO synthase activity in renal glomeruli and collecting tubules, but this effect is less pronounced and short lasting. During the first week after injection of bendazol, insignificant elevation of NO synthase activity is observed in the proximal nephron segments.[1]

[1] E V Eliseeva, et al. Bull Exp Biol Med. 2017 Jan;162(3):357-361. [2] Liyang Tong, et al. Ophthalmic Physiol Opt. 2020 Sep;40(5):567-576.

Chemical Properties

Cas No. 621-72-7 SDF
别名 地巴唑
Canonical SMILES C1(CC2=CC=CC=C2)=NC3=CC=CC=C3N1
分子式 C14H12N2 分子量 208.26
溶解度 DMSO : 42mg/mL 储存条件 Store at -20°C
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1 mM 4.8017 mL 24.0085 mL 48.0169 mL
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Research Update

Topical Bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits

Ophthalmic Physiol Opt 2020 Sep;40(5):567-576.PMID:32839973DOI:10.1111/opo.12717.

Purpose: To investigate the inhibitory effect of Bendazol on form-deprivation myopia (FDM) in rabbits as well as the underlying biochemical processes. Methods: Forty-eight 3-week-old New Zealand white rabbits were randomly assigned to three groups: a control group, a form-deprivation (FD) group and an FD + Bendazol group (treated with 1% Bendazol in the FD eyes). Refraction, corneal curvature, vitreous chamber depth (VCD) and axial length (AL) were assessed using streak retinoscopy, keratometry, and A-scan ultrasonography, respectively. Eyeballs were enucleated for histological analysis, and ocular tissues were homogenized to determine the mRNA and protein expression of hypoxia-inducible factor-1α (HIF-1α) and muscarinic acetylcholine receptors (mAChRs). Results: Bendazol inhibited the progression of FDM and suppressed the upregulation of HIF-1α. At week 6, in the control, FD and FD + Bendazol groups, the refraction values were 1.38 ± 0.43, 0.03 ± 0.47 and 1.25 ± 0.35 D, respectively (p < 0.001); the ALs were 13.91 ± 0.11, 14.15 ± 0.06 and 13.97 ± 0.10 mm, respectively (p < 0.001) and the VCDs were 6.56 ± 0.06, 6.69 ± 0.07 and 6.61 ± 0.06 mm, respectively (p < 0.001). HIF-1α was upregulated in FD eyes but downregulated in FD + Bendazol eyes, while the mAChRs were the opposite. Conclusions: In the FD rabbit model, Bendazol significantly inhibits the development of myopia and downregulates HIF-1α expression, which may provide a novel therapeutic approach for myopia control.

[Effect of dibazol (Bendazol) on the generative function in rats]

Eksp Klin Farmakol 2007 Mar-Apr;70(2):37-9.PMID:17523449doi

The ambiguous influence of Bendazol (5 and 160 mg/kg) on the sexual behavior and spermatogenesis of rats was observed in experiments on male rats. An increase in the duration of sexual activity and a decrease of the total amount of spermatozoons were registered irrespective of the course of drug administration in a dose of 5 mg/kg. In males treated with Bendazol in a dose of 160 mg/kg, the behavior varied depending on the duration of treatment: the sexual activity decreased upon a 5-day treatment and increased after a 2-month course. The index of spermatogenesis did not depend on the time of administration at 5 or 160 mg/kg, while the spermatozoon mobility was suppressed upon the short-term treatment and increased upon the log-term administration of Bendazol.

Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension

Bull Exp Biol Med 2017 Jan;162(3):357-361.PMID:28091926DOI:10.1007/s10517-017-3615-3.

An original model of nephrogenic hypertension in rats was used for histochemical mapping of NADPH diaphorase (NO synthase) in various renal segments to examine the effect of hypotensive drugs furosemide, Bendazol, and clonidine on the time course of nitroxide production in the kidneys. In various nephron segments, these drugs modulated NO synthesis in different ways. Clonidine induced a stable up-regulation of NO synthesis, which can maintain active vasodilation and gradually diminish the rennin production. Bendazol also enhanced NO synthase activity in renal glomeruli and collecting tubules, but this effect was less pronounced and short lasting. During the first week after injection of Bendazol, insignificant elevation of NO synthase activity was observed in the proximal nephron segments. Furosemide exerted the least effect on NO production in kidneys.

Albendazole in the treatment of Hymenolepiasis in school children

Pak J Pharm Sci 2018 Jan;31(1(Suppl.)):305-309.PMID:29386158doi

Hymenolepiasis is a helminthic and occasionally fatal disease of human imposing heavy economic losses to human society. Present study was aimed to diagnose the school children for the prevalence and control of Hymenolepiasis. A school based cross-sectional analysis of stool samples collected from 188 children aged 06-15 years was carried out (February to June 2016). Two stool samples were collected from each student before diagnosing and after treatment. The samples were fixed in 10% formalin and observed under the light microscope using the methods of direct smear in Lugol's solution, normal saline and flotation techniques. On the basis of drugs accessibility all the H. nana infected children were divided in to 2- groups. Children in group A were treated with albendazole (Bendazol) 400mg once orally, group B was treated with albendazole (zentel) 200mg orally. Eggs per gram of faeces were counted in each group before and after treatment. Of the 188 children, current study reveals only 6.08% (n=18/296) infection with H.nana and 10.5% (n=16/151) were diagnosed with co infections. The % efficacy of albendazole (Zentel) and albendazole (Bendazol) against Hymenolepis nana infection was reported as 83% and 75% respectively. Present study was concluded that albendazole (zentel) is the drug of choice for the treatment of hymenolepiasis in children.

Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres

J Sep Sci 2020 Jan;43(2):389-397.PMID:31631562DOI:10.1002/jssc.201900634.

Vinyl, chloropropyl, and mercaptopropyl functionalized particles were prepared by a two-step acidic/alkaline catalyzed co-hydrolysis/condensation of methyltrimethoxysilane with a different silane precursor that carries chemically reactive functional group including vinyl, chloropropyl, and mercaptopropyl, respectively. The morphology, pore structure, and functional groups of the synthesized packings were studied by SEM, nitrogen adsorption-desorption measurements, and solid-state 13 C 29 Si NMR spectroscopy, respectively. The particles show ordered sphere, narrow particle size distribution, and mesoporous structure. The carbon contents of the microspheres are in the range of 17-19%, comparable to those of octadecyl-bonded silica packings. The three-kind of microspheres were directly used as packing materials for high-performance liquid chromatography without size classification. The chromatographic performance of the columns was evaluated and compared with a commercially available C18 phase. The results revealed that these columns possess typical reversed-phase chromatographic properties with increased hydrophobicity than polymethylsilsesquioxane and symmetric peaks for basic compounds. They were applied to the simultaneous separation of combination Bendazol hydrochlorothiazide capsules containing polar and basic drugs with peaks identified by tandem with mass spectrometry. In general, a novel method is provided for the synthesis of different methyltrimethoxysilane-derived microspheres for high-performance liquid chromatography, which are advantageous for separating basic compounds.