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B.Microti IRA

目录号 : GP22823

Babesia Microti IRA Recombinant

B.Microti IRA Chemical Structure

规格 价格 库存 购买数量
50μg
¥9,800.00
5-10工作日
100μg
¥14,000.00
5-10工作日
1mg
¥63,000.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Recombinant Babesia Microti IRA produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 77,554 Dalton. B.Microti IRA is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.

Product Data

Purity Greater than 80.0% as determined by SDS-PAGE. Source Sf9 insect cells.
Phycical Appearance Sterile Filtered clear solution. Shipping Condition Shipped with Ice Packs.
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Formulation B.Microti IRA is supplied in 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol.

Introduction

Babesiosis is a disease caused by apicomplexan parasites of the Babesia genus. The Babesia microti life cycle involves 2 hosts, which include a rodent, mainly the white-footed mouse (Peromyscus leucopus) and a tick in the Ixodes genus. During a blood meal, a Babesia-infected tick introduces sporozoites into the mouse host. Sporozoites pass into the erythrocytes and undergo asexual reproduction (budding). In the blood, some parasites differentiate into male and female gametes, though these cannot be distinguished by light microscopy. The definitive host is the tick. Once ingested by an proper tick, gametes unite and undergo a sporogonic cycle resulting in sporozoites. Transovarial transmission (aka vertical or hereditary transmission) has been detected for "large" Babesia species but not for the "small" Babesia, such as B. microti. Humans enter the cycle when bitten by the infected ticks. Thus during a blood meal, a Babesia-infected tick introduces sporozoites into the human host. Sporozoites then enter erythrocytes and undergo asexual replication (budding). Multiplication of the blood-stage parasites is responsible for the clinical manifestations of the disease. Humans typically are dead-end hosts. However, human-to-human transmission is well acknowledged to occur via contaminated blood transfusions.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.