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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Sale

(Synonyms: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) 目录号 : GC34025

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) 是一种 28 个氨基酸的激素,通常由人类心脏对心脏损伤和机械拉伸的反应。

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Chemical Structure

Cas No.:1366000-58-9

规格 价格 库存 购买数量
500μg
¥1,607.00
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1mg
¥2,499.00
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5mg
¥8,747.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.

Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II[1]. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[2]. In glomeruli from normal rats, Human 125I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli[3].

[1]. Kohno M, et al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7. [2]. Kohno M, et al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004. [3]. Ballermann BJ, et al. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli. J Clin Invest. 1985 Dec;76(6):2049-56.

Chemical Properties

Cas No. 1366000-58-9 SDF
别名 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate
Canonical SMILES Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
分子式 C127H203N45O39S3.C2H4O2 分子量 3140.5
溶解度 25mg/ml in Water 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.3184 mL 1.5921 mL 3.1842 mL
5 mM 0.0637 mL 0.3184 mL 0.6368 mL
10 mM 0.0318 mL 0.1592 mL 0.3184 mL
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