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Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Sale

(Synonyms: Angiotensin (5-8)) 目录号 : GC46856

An endogenous angiotensin II fragment

Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Chemical Structure

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1 mg
¥1,352.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II .1 It inhibits renin release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre-contracted with phenylephrine .2,1 In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II.1 It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.3

1.Guethe, L.M., Pelegrini-da-Silva, A., Borelli, K.G., et al.Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioidNeuroscience231315-327(2013) 2.Naftilan, A.J., and Oparil, S.Inhibition of renin release from rat kidney slices by the angiotensinsAm. J. Physiol.235(1)F62-F68(1978) 3.Genaro, K., Juilano, M.A., Prado, W.A., et al.Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in ratsBehav. Brain Res.256537-544(2013)

Chemical Properties

Cas No. N/A SDF
别名 Angiotensin (5-8)
Canonical SMILES C[C@@H](CC)[C@]([H])(N)C(N[C@@H](CC1=CNC=N1)C(N2[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CCC2)=O)=O.OC(C(F)(F)F)=O
分子式 C26H36N6O5.XCF3COOH 分子量 512.6
溶解度 Water: 1 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.9508 mL 9.7542 mL 19.5084 mL
5 mM 0.3902 mL 1.9508 mL 3.9017 mL
10 mM 0.1951 mL 0.9754 mL 1.9508 mL
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