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Allopurinol Sale

(Synonyms: 别嘌醇) 目录号 : GC15322

Inhibitor of xanthine oxidase

Allopurinol Chemical Structure

Cas No.:315-30-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥378.00
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25g
¥651.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Target: XAOAllopurinol (Zyloprim, and generics) is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. It is a xanthine oxidase inhibitor which is administered orally. A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by Aldehyde oxidase. The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase. Allopurinol is almost completely metabolized to oxypurinol within two hours of oral administration, whereas oxypurinol is slowly excreted by the kidneys over 18–30 hours. For this reason, oxypurinol is believed responsible for the majority of allopurinol's effect.Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase. In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine. While xanthine cannot be converted to purine ribotides, hypoxanthine can be salvaged to the purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides may cause feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol, therefore, decreases uric acid formation and may also inhibit purine synthesis.

References:
[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.
[2]. Reiter S, et al. Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol. Clin Chim Acta. 1990 Mar 15;187(3):221-34.

Chemical Properties

Cas No. 315-30-0 SDF
别名 别嘌醇
化学名 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one
Canonical SMILES C1=C2C(=NC=NC2=O)NN1
分子式 C5H4N4O 分子量 136.11
溶解度 DMSO: 3 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml 储存条件 Store at RT
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 7.347 mL 36.735 mL 73.47 mL
5 mM 1.4694 mL 7.347 mL 14.694 mL
10 mM 0.7347 mL 3.6735 mL 7.347 mL
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