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Adenosine amine congener Sale

(Synonyms: ADAC) 目录号 : GC38884

An adenosine A1 receptor agonist

Adenosine amine congener Chemical Structure

Cas No.:96760-69-9

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10mM (in 1mL DMSO)
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5mg
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产品描述

Adenosine amine congener (ADAC) is an adenosine A1 receptor agonist.1,2 It selectively binds adenosine A1 over A2A and A3 receptors (Kis = 0.85, 210, and 281 nM, respectively, for the rat receptors).3 ADAC (75 ?g/kg) increases survival and prevents neuronal damage in the hippocampal CA1 region in a gerbil model of cerebral ischemia induced by bilateral carotid artery occlusion.1 It protects against auditory threshold shifts and inner and outer hair cell loss in rats following noise exposure at 110 dB when administered at a dose of 100 ?g/kg.2

1.Von Lubitz, D.K.J.E., Lin, R.C.-S., Bischofberger, N., et al.Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonistEur. J. Pharmacol.369(3)313-317(1999) 2.Vlajkovic, S.M., Lee, K.-H., Wong, A.C.Y., et al.Adenosine amine congener mitigates noise-induced cochlear injuryPurinergic Signal.6(2)273-281(2010) 3.Karl, M.O., Fleischhauer, J.C., Stamer, W.D., et al.Differential P1-purinergic modulation of human Schlemm’s canal inner-wall cellsAm. J. Physiol. Cell Physiol.288(4)C784-C794(2005)

Chemical Properties

Cas No. 96760-69-9 SDF
别名 ADAC
Canonical SMILES OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3NC4=CC=C(CC(NC5=CC=C(CC(NCCN)=O)C=C5)=O)C=C4)O1)O)O
分子式 C28H32N8O6 分子量 576.6
溶解度 DMSO: 31.25 mg/mL (54.20 mM) 储存条件 Store at -20°C
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Research Update

Adenosine amine congener mitigates noise-induced cochlear injury

Purinergic Signal 2010 Jun;6(2):273-81.PMID:20806018DOI:10.1007/s11302-010-9188-5.

Hearing loss from noise exposure is a leading occupational disease, with up to 5% of the population at risk world-wide. Here, we present a novel purine-based pharmacological intervention that can ameliorate noise-induced cochlear injury. Wistar rats were exposed to narrow-band noise (8-12 kHz, 110 dB SPL, 2-24 h) to induce cochlear damage and permanent hearing loss. The selective adenosine A(1) receptor agonist, Adenosine amine congener (ADAC), was administered intraperitoneally (100 microg/kg/day) at time intervals after noise exposure. Hearing thresholds were assessed using auditory brainstem responses and the hair cell loss was evaluated by quantitative histology. Free radical damage in the organ of Corti was assessed using nitrotyrosine immunohistochemistry. The treatment with ADAC after noise exposure led to a significantly greater recovery of hearing thresholds compared with controls. These results were upheld by increased survival of sensory hair cells and reduced nitrotyrosine immunoreactivity in ADAC-treated cochlea. We propose that ADAC could be a valuable treatment for noise-induced cochlear injury in instances of both acute and extended noise exposures.

Adenosine amine congener as a cochlear rescue agent

Biomed Res Int 2014;2014:841489.PMID:25243188DOI:10.1155/2014/841489.

We have previously shown that Adenosine amine congener (ADAC), a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. Here we demonstrate the dose-dependent rescue effects of ADAC on noise-induced cochlear injury in a rat model and establish the time window for treatment. Methods: ADAC (25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration. Results: ADAC was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products. Conclusion: Our data show that ADAC mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment.

Pharmacokinetic Properties of Adenosine amine congener in Cochlear Perilymph after Systemic Administration

Biomed Res Int 2017;2017:8091462.PMID:28194422DOI:10.1155/2017/8091462.

Noise-induced hearing loss (NIHL) is a global health problem affecting over 5% of the population worldwide. We have shown previously that acute noise-induced cochlear injury can be ameliorated by administration of drugs acting on adenosine receptors in the inner ear, and a selective A1 adenosine receptor agonist Adenosine amine congener (ADAC) has emerged as a potentially effective treatment for cochlear injury and resulting hearing loss. This study investigated pharmacokinetic properties of ADAC in rat perilymph after systemic (intravenous) administration using a newly developed liquid chromatography-tandem mass spectrometry detection method. The method was developed and validated in accordance with the USA FDA guidelines including accuracy, precision, specificity, and linearity. Perilymph was sampled from the apical turn of the cochlea to prevent contamination with the cerebrospinal fluid. ADAC was detected in cochlear perilymph within two minutes following intravenous administration and remained in perilymph above its minimal effective concentration for at least two hours. The pharmacokinetic pattern of ADAC was significantly altered by exposure to noise, suggesting transient changes in permeability of the blood-labyrinth barrier and/or cochlear blood flow. This study supports ADAC development as a potential clinical otological treatment for acute sensorineural hearing loss caused by exposure to traumatic noise.

Protection against ischemic damage by Adenosine amine congener, a potent and selective adenosine A1 receptor agonist

Eur J Pharmacol 1999 Mar 26;369(3):313-7.PMID:10225368DOI:10.1016/s0014-2999(99)00073-4.

Although the selectivity and potency of Adenosine amine congener (ADAC) at adenosine A1 receptors are similar to other highly selective agonists at this receptor type, the chemical structure of the N6 substituent is completely different. We now demonstrate that the characteristics of the therapeutic profile of ADAC are distinct from those observed during our previous studies of adenosine A1 receptor agonist-mediated neuroprotection. Most significantly, chronic treatment with low microgram doses of ADAC (25-100 microg/kg) protects against both mortality and neuronal damage induced by 10 min bilateral carotid occlusion in gerbils. At higher chronic doses, the statistical significance of the protective effect is lost. Acute preischemic administration of the drug at 75-200 microg/kg also results in a statistically significant reduction of postischemic mortality and morbidity. These data indicate that, contrary to other adenosine A1 receptor agonists whose chronic administration enhances postocclusive brain damage, ADAC may be a promising agent in treatment of both acute (e.g., cerebral ischemia) and chronic (seizures) disorders of the central nervous system in which adenosine A receptors appear to be involved.

Postischemic administration of Adenosine amine congener (ADAC): analysis of recovery in gerbils

Eur J Pharmacol 1996 Dec 5;316(2-3):171-9.PMID:8982684DOI:10.1016/s0014-2999(96)00667-x.

Although adenosine receptor-based treatment of cerebral ischemia and other neurodegenerative disorders has been frequently advocated, cardiovascular side effects and an uncertain therapeutic time window of such treatment have constituted major obstacles to clinical implementation. Therefore, we have investigated the neuroprotective effects of the adenosine A1 receptor agonist Adenosine amine congener (ADAC) injected after either 5 or 10 min ischemia at 100 micrograms/kg. When the drug was administered at either 6 or 12 h following 5 min forebrain ischemia, all animals were still alive on the 14th day after the occlusion. In both ADAC treated groups neuronal survival was approximately 85% vs. 50% in controls. Administration of a single dose of ADAC at times 15 min to 12 h after 10 min ischemia resulted in a significant improvement of survival in animals injected either at 15 or 30 min, or at 1, 2, or 3 h after the insult. In all 10 min ischemia groups, administration of ADAC resulted in a significant protection of neuronal morphology and preservation of microtubule associated protein 2 (MAP-2). However, postischemic Morris' water maze tests revealed full preservation of spatial memory and learning ability in animals injected at 6 h. On the other hand, the performance of gerbils treated at 12 h postischemia was indistinguishable from that of the controls. Administration of ADAC at 100 micrograms/kg in non-ischemic animals did not result in bradycardia, hypotension, or hypothermia. The data indicate that when ADAC is used postischemically, the most optimal level of protection is obtained when drugs are given at 30 min to 6 h after the insult. Although the mechanisms involved in neuroprotective effects of adenosine A1 receptor agonists require further studies, the present results demonstrate the feasibility of their clinical applications.