Acefylline (Theophyllineacetic acid)
(Synonyms: 茶碱乙酸; Theophyllineacetic acid; Theophylline-7-acetic acid) 目录号 : GC34143
An Analytical Reference Standard
Cas No.:652-37-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Acefylline is an analytical reference standard categorized as a respiratory stimulant.1 This product is intended for research and forensic applications.
1.Jain, K.S., Arya, N., Inamdar, N.N., et al.The chemistry and bio-medicinal significance of pyrimidines & condensed pyrimidinesCurr. Top. Med. Chem.16(28)3133-3174(2016)
| Cas No. | 652-37-9 | SDF | |
| 别名 | 茶碱乙酸; Theophyllineacetic acid; Theophylline-7-acetic acid | ||
| Canonical SMILES | O=C(O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O | ||
| 分子式 | C9H10N4O4 | 分子量 | 238.2 |
| 溶解度 | DMSO : 17 mg/mL (71.37 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1982 mL | 20.9908 mL | 41.9815 mL |
| 5 mM | 0.8396 mL | 4.1982 mL | 8.3963 mL |
| 10 mM | 0.4198 mL | 2.0991 mL | 4.1982 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether
The kinetics of esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether in the presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine as catalyst was studied. According to the known mechanism, besides the main process, the side-reaction of intramolecular rearrangement with formation of pharmacologically active N-acylurea occurs. The course of the main and the side-process was monitored by RP-HPLC with UV-detection. For that purpose, quantification of both ester and N-acylurea in the reaction mixture was performed. Influence of the concentration of the reactants (acid, alcohol and catalyst) on the progress of esterification and preparation of the by-product was investigated. Based on the obtained results, the reaction conditions leading to maximal yield of the ester and N-acylurea are proposed. The possibility of turning esterification to the synthesis of the side-product was also found. Reactions of the preparation of both the ester and N-acylurea were found to follow first-order kinetics. The rate constants of both processes were estimated.
[Amides of 7-theophyllineacetic acid with antiarrhythmic action]
[The synthesis and anti-inflammatory properties of 7-theophyllineacetic acid derivatives]
Some esters of 7-theophyllinylacetic acid were synthetized, characterized physicochemically and tested for their anti-inflammatory properties. As compared to indomethacin, reference anti-inflammatory drug, all synthetized compounds were less toxic. The anti-inflammatory properties are influenced by the nature of the ester group radicals, the more active having ramified alchils.