Home>>Signaling Pathways>> Proteases>> Endogenous Metabolite>>α-Muricholic Acid

α-Muricholic Acid

(Synonyms: 5β-Cholanic Acid-3α,6β,7α-triol) 目录号 : GC40718

A murine-specific primary bile acid

α-Muricholic Acid Chemical Structure

Cas No.:2393-58-0

规格 价格 库存 购买数量
1mg
¥1,627.00
现货
5mg
¥5,705.00
现货
10mg
¥10,586.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

α-Muricholic acid is a murine-specific primary bile acid.[1]  Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids.[2] [3] Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.[4]

Reference:
[1]. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).
[2]. Uehara, T., Xi Peng, X., Bennett, B., et al. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation 78(3), 324-332 (2004).
[3]. Watanabe, K., Igarashi, M., Li, X., et al. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids. PLoS One 13(8), e0202083 (2018).
[4]. La Frano, M.R., Hernandez-Carretero, A., Weber, N., et al. Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J mice. Nutr. Res. 46, 11-21 (2017).

Chemical Properties

Cas No. 2393-58-0 SDF
别名 5β-Cholanic Acid-3α,6β,7α-triol
化学名 (3α,5β,6β,7α)-3,6,7-trihydroxy-cholan-24-oic acid
Canonical SMILES C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式 C24H40O5 分子量 408.6
溶解度 20mg/mL in ethanol, or in DMSO, 30mg/mL in DMF 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.4474 mL 12.2369 mL 24.4738 mL
5 mM 0.4895 mL 2.4474 mL 4.8948 mL
10 mM 0.2447 mL 1.2237 mL 2.4474 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置