5-Tricosylresorcinol
(Synonyms: 5-二十三烷基间苯二酚) 目录号 : GC46079
An alkylresorcinol
Cas No.:70110-60-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
5-Tricosylresorcinol is an alkylresorcinol that has been found in wheat, rye, triticale, and barley.1 It reduces hydrogen peroxide-induced DNA damage in HT-29 cells when used at a concentration of 100 μM.2
|1. Ross, A.B., Shepherd, M.J., SchÜpphaus, M., et al. Alkylresorcinols in cereals and cereal products. J. Agric. Food Chem. 51(14), 4111-4118 (2003).|2. Parikka, K., Rowland, I.R., Welch, R.W., et al. In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols. J. Agric. Food Chem. 54(5), 1646-1650 (2006).
| Cas No. | 70110-60-0 | SDF | |
| 别名 | 5-二十三烷基间苯二酚 | ||
| Canonical SMILES | OC1=CC(O)=CC(CCCCCCCCCCCCCCCCCCCCCCC)=C1 | ||
| 分子式 | C29H52O2 | 分子量 | 432.7 |
| 溶解度 | Ethanol: soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3111 mL | 11.5554 mL | 23.1107 mL |
| 5 mM | 0.4622 mL | 2.3111 mL | 4.6221 mL |
| 10 mM | 0.2311 mL | 1.1555 mL | 2.3111 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The Impact of Some Natural Phenolic Compounds on α-Glucosidase and Sorbitol Dehydrogenase Enzymes, and Anti-leukemia Cancer Potential, Spin Density Distributions, and in silico Studies
J Oleo Sci 2022 Jun 3;71(6):863-873.PMID:35584958DOI:10.5650/jos.ess22029
In this study, some phenolic compounds including 4-Hexylresorcinol, 5-Pentadecylresorcinol, 5-Tricosylresorcinol, Bilobol, and Urushiol were tested against α-glycosidase enzyme from Saccharomyces cerevisiae and sorbitol dehydrogenase enzymes from sheep liver. These compounds determined good inhibition properties against α-glycosidase and sorbitol dehydrogenase (SDH) enzymes. IC50 values were record in the range of 1.45±0.20-24.532±3.83 μM for α-glycosidase and 6.20±0.96-108.22±18.02 μM for SDH. These inhibitor compounds can be selective drug candidates as anti-diabetic agents, because of they have inhibition properties against both enzymes. In this study, the anti-oxidant activities of the molecules were compared with density functional theory (DFT) calculations. Comparison was made with the experimental enzymes by molecular modeling calculations. In the cellular and molecular part of the recent study, the treated cells with some phenolic compounds were assessed by molecularly targeted therapy (MTT) assay for cytotoxicity and anti-acute lymphoblastic leukemia potentials on Clone 15 HL-60, HL-60, HL-60/MX1, and HL-60/MX2 cell lines. The IC50 of these compounds were µg/mL level against these cell lines.