5α-dihydro-11-keto Testosterone-d3
(Synonyms: 5α-Androstane-3,11-dione-17β-ol-d3, 17β-hydroxy-5α-Androstane-3,11-dione-d3, 11-keto Dihydrotestosterone-d3) 目录号 : GC46717
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
5α-dihydro-11-keto Testosterone-d3 is intended for use as an internal standard for the quantification of 5α-dihydro-11-keto testosterone by GC- or LC-MS. 5α-dihydro-11-keto Testosterone is a metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has been shown to act as a full androgen receptor agonist with equal potency as that of dihydrotestosterone .1,2,3 The androgenic activity of 5α-dihydro-11-keto testosterone has been implicated in contributing to the androgen pool that drives castration-resistant prostate cancer cells.2,3
1.Bloem, L.M., Storbeck, K.-H., Schloms, L., et al.11β-hydroxyandrostenedione returns to the steroid arena: Biosynthesis, metabolism and functionMolecules18(11)13228-13244(2013) 2.Swart, A.C., and Storbeck, K.-H.11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathwayMol. Cell. Endocrinol.408114-123(2015) 3.Storbeck, K.-H., Bloem, L.M., Africander, D., et al.11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer•Mol. Cell. Endocrinol.377(1-2)135-146(2013)
| Cas No. | N/A | SDF | |
| 别名 | 5α-Androstane-3,11-dione-17β-ol-d3, 17β-hydroxy-5α-Androstane-3,11-dione-d3, 11-keto Dihydrotestosterone-d3 | ||
| Canonical SMILES | O[C@@]1([2H])C([2H])([2H])C[C@@]([C@]1(C)C2)([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])C2=O)=O | ||
| 分子式 | C19H25D3O3 | 分子量 | 307.4 |
| 溶解度 | DMF: 20 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL,Ethanol: 20 mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2531 mL | 16.2655 mL | 32.5309 mL |
| 5 mM | 0.6506 mL | 3.2531 mL | 6.5062 mL |
| 10 mM | 0.3253 mL | 1.6265 mL | 3.2531 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。