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4-Hydroxypropranolol-d7 Sale

(Synonyms: (±)-4-Hydroxy Propranolol-d7) 目录号 : GC64116

4-Hydroxypropranolol-d7 ((±)-4-Hydroxy Propranolol-d7) 是 4-Hydroxypropranolol hydrochloride 的氘代物。4-Hydroxypropranolol hydrochloride 是 Propranolol 的活性代谢产物。4-Hydroxypropranolol hydrochloride 的效力与 Propranolol 相当。4-Hydroxypropranolol hydrochloride 抑制 β1-和 β2-肾上腺素能受体,pA2 值分别为 8.24 和 8.26。4-Hydroxypropranolol hydrochloride 具有固有的拟交感活性,膜稳定活性和强效的抗氧化性能。

4-Hydroxypropranolol-d7 Chemical Structure

Cas No.:1219908-86-7

规格 价格 库存 购买数量
1 mg
¥4,050.00
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5 mg
¥13,500.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

4-Hydroxypropranolol-d7 ((±)-4-Hydroxy Propranolol-d7) is the deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35.
[3]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61.
[4]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

Chemical Properties

Cas No. 1219908-86-7 SDF Download SDF
别名 (±)-4-Hydroxy Propranolol-d7
分子式 C16H14D7NO3 分子量 282.39
溶解度 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5412 mL 17.706 mL 35.412 mL
5 mM 0.7082 mL 3.5412 mL 7.0824 mL
10 mM 0.3541 mL 1.7706 mL 3.5412 mL
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