4-(1,2-Dihydroxyethyl)benzene-1,2-diol
(Synonyms: DL-3,4-二羟基苯基二醇) 目录号 : GC31640
An active metabolite of norepinephrine
Cas No.:28822-73-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
DL-3,4-Dihydroxyphenyl glycol is an active metabolite of the endogenous neurotransmitter norepinephrine .1 It is produced by the deamination of norepinephrine by monoamine oxidase (MAO) in the cytosol.2 DL-3,4-Dihydroxyphenyl glycol scavenges DPPH radicals in a cell-free assay (IC50 = 1.55 ?M).3 It reduces LPS-induced nitrite production in isolated mouse peritoneal macrophages when used at concentrations of 50 and 100 ?M. DL-3,4-Dihydroxyphenyl glycol (50 and 100 ?M) decreases increases in inducible nitric oxide synthase (iNOS) and COX-2 levels induced by LPS in isolated mouse macrophages. It also inhibits LPS-induced degradation of IκBα in isolated mouse macrophages.
1.Jonason, J., and Rutledge, C.O.The effect of protriptyline on the metabolism of dopamine and noradrenaline in rabbit brain in vitroActa Physiol. Scand.73(1)161-175(1968) 2.Padala, N.S.P., Ajjala, D.R., Boggavarapu, R.K., et al.LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regionsBioanalysis11(10)971-986(2019) 3.Aparicio-Soto, M., Sánchez-Fidalgo, S., González-Benjumea, A., et al.Naturally occurring hydroxytyrosol derivatives: Hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplementsJ. Agric. Food Chem.63(3)836-846(2015)
| Cas No. | 28822-73-3 | SDF | |
| 别名 | DL-3,4-二羟基苯基二醇 | ||
| Canonical SMILES | C1=CC(=C(C=C1C(CO)O)O)O | ||
| 分子式 | C8H10O4 | 分子量 | 170.16 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.8768 mL | 29.3841 mL | 58.7682 mL |
| 5 mM | 1.1754 mL | 5.8768 mL | 11.7536 mL |
| 10 mM | 0.5877 mL | 2.9384 mL | 5.8768 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。