3-Methoxytyrosine |
| 目录号 GC49869 |
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
-
Purity: >95.00%
- COA (Certificate Of Analysis)
- Datasheet
3-Methoxytyrosine is an active metabolite of L-DOPA .1 It is formed from L-DOPA via O-methylation by catechol-O-methyltransferase (COMT). 3-Methoxytyrosine (10 and 100 µM) inhibits L-DOPA-induced neuroprotection in primary rat mesencephalic dopaminergic neurons.2
1.Miller, J.W., Shukitt-Hale, B., Villalobos-Molina, R., et al.Effect of ?-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in ratsClin. Neuropharmacol.20(1)55-66(1997) 2.Asanuma, M., and Miyazaki, I.3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of ?-DOPABMC Neurosci.17(1)52(2016)
| Cas No. | 7636-26-2 | SDF | Download SDF |
| 别名 | N/A | ||
| 化学名 | N/A | ||
| Canonical SMILES | O=C(C(CC1=CC=C(C(OC)=C1)O)N)O | ||
| 分子式 | C10H13NO4 | 分子量 | 211.2 |
| 溶解度 | Acetonitrile: Slightly soluble,Chloroform: Slightly soluble,DMF: Slightly soluble,DMSO: Slightly soluble,PBS (pH 7.2): Slightly soluble,Water: Slightly soluble | 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % ddH2O | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。