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21-Deoxycortisol-d8 Sale

(Synonyms: 21-Dehydrohydrocortisone-d8) 目录号 : GC49611

An internal standard for the quantification of 21-deoxycortisol

21-Deoxycortisol-d8 Chemical Structure

Cas No.:2479914-04-8

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1 mg
¥3,474.00
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5 mg
¥15,640.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

21-Deoxycortisol-d8 is intended for use as an internal standard for the quantification of 21-deoxycortisol by GC- or LC-MS. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11β-hydroxylase.1,2 Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiencyAnn. Clin. Biochem.31(Pt. 1)56-64(1994) 2.Cristoni, S., Cuccato, D., Sciannamblo, M., et al.Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoringRapid Commun. Mass Spectrom.18(1)77-82(2004)

Chemical Properties

Cas No. 2479914-04-8 SDF Download SDF
别名 21-Dehydrohydrocortisone-d8
Canonical SMILES C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])[2H])=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C
分子式 C21H22D8O4 分子量 354.5
溶解度 DMSO: soluble 储存条件 -20°C
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1 mg 5 mg 10 mg
1 mM 2.8209 mL 14.1044 mL 28.2087 mL
5 mM 0.5642 mL 2.8209 mL 5.6417 mL
10 mM 0.2821 mL 1.4104 mL 2.8209 mL
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