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2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) Sale

(Synonyms: 6-羟基-2-氨甲基嘌呤,N2-methylguanine) 目录号 : GC33496

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) (N2-Methylguanine) 是一种修饰的核苷。

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) Chemical Structure

Cas No.:10030-78-1

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10mM (in 1mL DMSO)
¥1,472.00
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5mg
¥1,339.00
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10mg
¥2,142.00
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50mg
¥6,694.00
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100mg
¥10,710.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

N2-Methylguanine is a modified nucleoside. N2-Methylguanine is an endogenous methylated nucleoside found in human fluids.

N2-methylguanine is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of N2-methylguanine substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[1]. N2-methylguanine is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of N2-methylguanine in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2].

[1]. Rife JP, et al. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Res. 1998 Aug 15;26(16):3640-4. [2]. Youvan DC, et al. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3751-4.

Chemical Properties

Cas No. 10030-78-1 SDF
别名 6-羟基-2-氨甲基嘌呤,N2-methylguanine
Canonical SMILES O=C1N=C(NC)NC2=C1NC=N2
分子式 C6H7N5O 分子量 165.15
溶解度 DMSO : < 1 mg/mL (insoluble or slightly soluble) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 6.0551 mL 30.2755 mL 60.551 mL
5 mM 1.211 mL 6.0551 mL 12.1102 mL
10 mM 0.6055 mL 3.0276 mL 6.0551 mL
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