2,2'-Bipyridine-5,5'-dicarboxylic Acid
(Synonyms: 2,2'-联吡啶-5,5'-二羧酸) 目录号 : GC46055
A heterocyclic building block
Cas No.:1802-30-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
2,2'-Bipyridine-5,5'-dicarboxylic acid is a heterocyclic building block.1,2 It has been used in the synthesis of metal-organic frameworks for water oxidation, organic photocatalysis, and carbon dioxide reduction.
|1. Bloch, E.D., Britt, D., Lee, C., et al. Metal insertion in a microporous metal-organic framework lined with 2,2'-bipyridine. J. Am. Chem. Soc. 132(41), 14382-14384 (2010).|2. Wang, C., Xie, Z., deKrafft, K.E., et al. Doping metal-organic frameworks for water oxidation, carbon dioxide reduction, and organic photocatalysis. J. Am. Chem. Soc. 133(34), 13445-13454 (2011).
| Cas No. | 1802-30-8 | SDF | |
| 别名 | 2,2'-联吡啶-5,5'-二羧酸 | ||
| Canonical SMILES | OC(C1=CC=C(C2=NC=C(C(O)=O)C=C2)N=C1)=O | ||
| 分子式 | C12H8N2O4 | 分子量 | 244.2 |
| 溶解度 | DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.095 mL | 20.475 mL | 40.95 mL |
| 5 mM | 0.819 mL | 4.095 mL | 8.19 mL |
| 10 mM | 0.4095 mL | 2.0475 mL | 4.095 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
2,2'-Bipyridine-5,5'-dicarboxylic Acid
Acta Crystallogr Sect E Struct Rep Online 2009 Aug 8;65(Pt 9):o2081.PMID:21577499DOI:10.1107/S1600536809030207.
The title mol-ecule, C(12)H(8)N(2)O(4), lies on an inversion center. In the crystal structure, inter-molecular O-H⋯O hydrogen bonds connect mol-ecules into one-dimensional chains along [11].
Poly[bis(mu3-5'-carboxy-2,2'-bipyridine-5-carboxylato-kappa4O:N,N':O')lead(II)]
Acta Crystallogr C 2009 Dec;65(Pt 12):m491-3.PMID:19966436DOI:10.1107/S0108270109047015.
The title compound, [Pb(C(12)H(7)N(2)O(4))(2)](n), obtained by reaction of Pb(NO(3))(2) and 2,2'-Bipyridine-5,5'-dicarboxylic Acid (H(2)bptc) under hydrothermal conditions, has a structure in which the unique Pb(II) cation sits on a twofold axis and is octa-coordinated by four O-atom donors from four Hbptc(-) ligands and four N-atom donors from two Hbptc(-) ligands in a distorted dodecahedral geometry. With each Pb(II) cation connected to six Hbptc(-) ligands and each Hbptc(-) ligand bridging three Pb(II) cations, a three-dimensional polymeric structure is formed. From a topological point of view, the three-dimensional net is binodal, with six-connected (the Pb(II) cation) and three-connected (the Hbptc(-) ligand) nodes, resulting in a distorted rutile (4(2).8)(2)(4(4)8(9)12(2)) topology.
Protection against Cu(II)-induced oxidative stress and toxicity to Chlorella vulgaris by 2,2'-Bipyridine-5,5'-dicarboxylic Acid
Arch Environ Contam Toxicol 2014 Apr;66(3):400-6.PMID:24323135DOI:10.1007/s00244-013-9977-2.
In this study, we evaluated the role of 2,2'-Bipyridine-5,5'-dicarboxylic Acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). Both in vivo and in vitro tests were performed. Different addition orders of Bpy-COOH and Cu(II) were tried in the former, whereas different Bpy-COOH concentrations were used in both experiments. The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). Based on these results, it could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes.
Copper-Curcumin-Bipyridine Dicarboxylate Complexes as Anticancer Candidates
Chem Biodivers 2022 Oct;19(10):e202200202.PMID:36163613DOI:10.1002/cbdv.202200202.
In this study, copper complexes with Curcumin (Cur) and 2,2'-Bipyridine-5,5'-dicarboxylic Acid (BPYD) were synthesized and their cytotoxicity on the MDA-MB-231 cell lines was evaluated. The resulting complex was characterized using FTIR, UV/VIS, CHNS, TGA, ICP-MS, and Mass spectroscopy techniques. The in-vitro cytotoxicity was studied on the MDA-MB-231 as a cancerous cell line and the HUVEC as a normal cell line. Reactive oxygen species (ROS) production was measured using the 2',7'-dichlorofluorescein diacetate (DCFDA) test in the MDA-MB-231 cancer cell lines. The in-vitro assays revealed that all synthesized copper complexes exhibited a higher cytotoxicity effect than carboplatin as a positive control on the MDA-MB-231 cells. While the synthesized complexes exhibited cytotoxic effects on cancerous cell lines, they are practically safe on normal cells. The Cu-Cur-BPYD complexes (a5 & b5) exhibited higher cytotoxicity on MDA-MB-231 cells with IC50 s around 4.9 and 2.3 mM, respectively. It can be concluded that the synthesized Cu-Cur-BPYD complexes (a5 & b5) could be considered effective anticancer candidates in complementary studies.
Application of a novel biomimetic double-ligand zirconium-based metal organic framework in environmental restoration and energy conversion
J Colloid Interface Sci 2022 Mar 15;610:136-151.PMID:34922071DOI:10.1016/j.jcis.2021.12.036.
The development of visible-light response photocatalysts with a high catalytic performance and long-term cyclic stability is of great significance in the field of energy and environmental protection. Inspired by photosynthesis, a novel three-dimensional coral zirconium-based metal organic framework (MOF) was synthesized using a double-ligand strategy. The optimal sample, Zr-TCPP-bpydc (2:1), (the ratio of tetra-(4-carboxyphenyl) porphyrin to 2,2'-Bipyridine-5,5'-dicarboxylic Acid is 2:1) shows an excellent photocatalytic activity under visible light irradiation, and the effects of the amount of photocatalyst, pH and concentration on the degradation rate were investigated under the optimum conditions. It has a high degradation rate of tetracycline (98.12% for tetracycline and 96.74% for ofloxacin), which is 2.11 times higher than that of single ligand Zr-bpydc (zirconium-based MOF containing only 2,2'-Bipyridine-5,5'-dicarboxylic Acid). More importantly, it also has a good H2 evolution rate (213.68 μmol g-1h-1) and CO2 reduction (35.81 μmol g-1h-1). In addition, the intermediate pathway of degradation, photocatalytic enhancement mechanism and cycle stability were deeply studied by liquid chromatography-mass spectrometry (LC-MS), electron spin resonance spectroscopy (ESR), linear sweep voltammetry (LSV) and recycling tests. The synthesis of a three-dimensional biomimetic coral zirconium-based MOF material will provide guidance for the development of new, promising, and natural ideal photocatalytic materials.