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15(R)-17-phenyl trinor Prostaglandin F2α Sale

(Synonyms: 贝美前列素杂质) 目录号 : GC40988

The 15(R)-isomer of the activated, free acid form of bimatoprost

15(R)-17-phenyl trinor Prostaglandin F2α Chemical Structure

Cas No.:41639-71-8

规格 价格 库存 购买数量
1mg
¥873.00
现货
5mg
¥3,941.00
现货
10mg
¥6,990.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 µg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or "unnatural" isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

Chemical Properties

Cas No. 41639-71-8 SDF
别名 贝美前列素杂质
Canonical SMILES O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@H](O)CCC2=CC=CC=C2)[C@H](O)C1
分子式 C23H32O5 分子量 388.5
溶解度 DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.574 mL 12.87 mL 25.74 mL
5 mM 0.5148 mL 2.574 mL 5.148 mL
10 mM 0.2574 mL 1.287 mL 2.574 mL
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