Home>>13,14-dihydro-16,16-difluoro Prostaglandin J2

13,14-dihydro-16,16-difluoro Prostaglandin J2 Sale

目录号 : GC46432

A neuropeptide with diverse biological activities

13,14-dihydro-16,16-difluoro Prostaglandin J2 Chemical Structure

规格 价格 库存 购买数量
100 μg
¥496.00
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500 μg
¥2,244.00
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1 mg
¥3,975.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Prostaglandin J2 (PGJ2) is an analog of PGD2 that can inhibit both platelet aggregation and cell growth.1,2,3 However, it is not clear whether these effects are initiated by PGJ2 or a derivative. 13,14-dihydro-16,16-difluoro PGJ2 is an analog of PGJ2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.4 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGJ2 could be biologically active.5,6

1.Bundy, G.L., Morton, D.R., Peterson, D.C., et al.Synthesis and platelet aggregation inhibiting activity of prostaglandin D analoguesJ. Med. Chem.26(6)790-799(1983) 2.Mahmud, I., Smith, D.L., Whyte, M.A., et al.On the identification and biological properties of prostaglandin J2Prostaglandins Leukot. Med.16(2)131-146(1984) 3.Fukushima, M.Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involvedEicosanoids3(4)189-199(1990) 4.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980) 5.ÄnggÅrd, E.The biological activities of three metabolites of prostaglandin E1Acta Physiologica Scandinavica66509-510(1966) 6.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES O=C1C=C[C@H](C/C=C\CCCC(O)=O)[C@H]1CC[C@@H](O)C(F)(F)CCCC
分子式 C20H30F2O4 分子量 372.5
溶解度 DMF: 14 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 15 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6846 mL 13.4228 mL 26.8456 mL
5 mM 0.5369 mL 2.6846 mL 5.3691 mL
10 mM 0.2685 mL 1.3423 mL 2.6846 mL
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