Home>>Signaling Pathways>> Proteases>> Lipoxygenase>>12-oxo Leukotriene B4

12-oxo Leukotriene B4

(Synonyms: 12keto LTB4, 12oxo LTB4) 目录号 : GC41096

A natural metabolite of LTB4

12-oxo Leukotriene B4 Chemical Structure

Cas No.:136696-10-1

规格 价格 库存
10μg
¥1,456.00
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25μg
¥3,101.00
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50μg
¥5,825.00
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100μg
¥10,193.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.

Chemical Properties

Cas No. 136696-10-1 SDF
别名 12keto LTB4, 12oxo LTB4
Canonical SMILES CCCCC/C=C\CC(=O)\C=C/C=C\C=C\[C@@H](O)CCCC(=O)O
分子式 C20H30O4 分子量 334.4
溶解度 DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS (pH 7.2): > 1 mg/ml 储存条件 Store at -80°C,protect from light
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1 mg 5 mg 10 mg
1 mM 2.9904 mL 14.9522 mL 29.9043 mL
5 mM 0.5981 mL 2.9904 mL 5.9809 mL
10 mM 0.299 mL 1.4952 mL 2.9904 mL
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