1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-PC
(Synonyms: 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphatidylcholine, PC(16:0/22:6), 16:0/22:6-PC, PDPC) 目录号 : GC46488A phospholipid
Cas No.:59403-54-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-PC (PDPC) is a phospholipid that contains palmitic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and HDL and has been found in atherosclerotic plaques.1,2 Enrichment of PDPC in recombinant HDLs decreases cholesterol ester formation by lecithin:cholesterol acyltransferase (LCAT) in vitro.3,4
1.Davis, B., Koster, G., Douet, L.J., et al.Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoproteinJ. Biol. Chem.283(10)6428-6437(2008) 2.MÉnÉgaut, L., Masson, D., Abello, N., et al.Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patientsAtherosclerosis251339-347(2016) 3.Parks, J.S., Thuren, T.Y., and Schmitt, J.D.Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 positionJ. Lipid Res.33(6)879-887(1992) 4.Parks, J.S., and Gebre, A.K.Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reactionJ. Lipid Res.38(2)266-275(1997)
| Cas No. | 59403-54-2 | SDF | |
| 别名 | 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphatidylcholine, PC(16:0/22:6), 16:0/22:6-PC, PDPC | ||
| Canonical SMILES | O=C(OC[C@@H](OC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)COP([O-])(OCC[N+](C)(C)C)=O)CCCCCCCCCCCCCCC | ||
| 分子式 | C46H80NO8P | 分子量 | 806.1 |
| 溶解度 | Chloroform: Slightly soluble | 储存条件 | Store at -80°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2405 mL | 6.2027 mL | 12.4054 mL |
| 5 mM | 0.2481 mL | 1.2405 mL | 2.4811 mL |
| 10 mM | 0.1241 mL | 0.6203 mL | 1.2405 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。