Cloxiquine (5-Chloro-8-quinolinol)
(Synonyms: 5-氯-8-羟基喹啉; 5-Chloro-8-quinolinol) 目录号 : GC32184
Cloxiquine (5-Chloro-8-quinolinol, Dermofungin) is an antibacterial, antifungal, antiaging and antituberculosis drug.
Cas No.:130-16-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Cloxiquine (5-Chloro-8-quinolinol, Dermofungin) is an antibacterial, antifungal, antiaging and antituberculosis drug.
| Cas No. | 130-16-5 | SDF | |
| 别名 | 5-氯-8-羟基喹啉; 5-Chloro-8-quinolinol | ||
| Canonical SMILES | OC1=C2N=CC=CC2=C(Cl)C=C1 | ||
| 分子式 | C9H6ClNO | 分子量 | 179.6 |
| 溶解度 | DMSO : ≥ 34 mg/mL (189.31 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.5679 mL | 27.8396 mL | 55.6793 mL |
| 5 mM | 1.1136 mL | 5.5679 mL | 11.1359 mL |
| 10 mM | 0.5568 mL | 2.784 mL | 5.5679 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by 鲁鈦礐l NQR, 鹿H-鹿鈦稯 and 鹿H-鹿鈦碞 NQDR and DFT/QTAIM
J Mol Model 2011 Jul;17(7):1781-800.PMID:21080020DOI:PMC3126996
The quinolinol derivatives clioquinol (5-chloro-7-iodo-8-quinolinol, Quinoform) and Cloxiquine (5-Chloro-8-quinolinol) were studied experimentally in the solid state via 鲁鈦礐l NQR, 鹿H-鹿鈦稯 and 鹿H-鹿鈦碞 NQDR spectroscopies, and theoretically by density functional theory (DFT). The supramolecular synthon pattern of O-H路路路N hydrogen bonds linking dimers and 蟺-蟺 stacking interactions were described within the QTAIM (quantum theory of atoms in molecules) /DFT (density functional theory) formalism. Both proton donor and acceptor sites in O-H路路路N bonds were characterized using 鹿H-鹿鈦稯 and 鹿H-鹿鈦碞 NQDR spectroscopies and QTAIM. The possibility of the existence of O-H路路路H-O dihydrogen bonds was excluded. The weak intermolecular interactions in the crystals of clioquinol and cloxiquine were detected and examined. The results obtained in this work suggest that considerable differences in the NQR parameters for the planar and twisted supramolecular synthons permit differentiation between specific polymorphic forms, and indicate that the more planar supramolecular synthons are accompanied by a greater number of weaker hydrogen bonds linking them and stronger 蟺路路路蟺 stacking interactions.