Home>>Signaling Pathways>> PROTAC>> PROTAC Linker>>TGN 020
TGN 020 目录号 GC50160

Aquaporin 4 (AQP4) channel blocker

规格 价格 库存 购买数量
10mM * 1 mL in DMSO
¥752.00
现货
10mg
¥680.00
现货
50mg
¥2,440.00
现货
100mg
¥4,160.00
现货

Customer Review

Based on customer reviews.

电话:400-920-5774 Email: sales@glpbio.cn

Sample solution is provided at 25 µL, 10mM.

质量管理

Quality Control & SDS

View current batch:

Chemical Properties

Cas No. 51987-99-6 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=C(NC1=NN=CS1)C2=CN=CC=C2
分子式 C8H6N4OS 分子量 206.22
溶解度 DMF: 100µ g/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2) (1:9): 100µ g/ml,Ethanol: 100µ g/ml 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
  • 摩尔浓度计算器

  • 稀释计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

产品描述

Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID:18182301 |Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID:23462267 |Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID:20924629