Virus Protease(病毒蛋白酶)

Cat.No. 产品名称 Information

GC69593 NS2B/NS3-IN-3 NS2B/NS3-IN-3 (Compd 66) 是 Flavivirus NS2B-NS3 蛋白酶的抑制剂。

GC69389 L-Lysine-d9 hydrochloride L-Lysine-d9 (hydrochloride) 是 L-Lysine 氘代物。L-lysine hydrochloride 人类必需的氨基酸，具有多种益处，可用于疱疹的研究，并能增加钙吸收，减少糖尿病相关疾病和改善肠道健康。

GC69350 LabMol-319 LabMol-319 是一种有效的寨卡病毒 (ZIKV) NS5 RdRp 抑制剂，IC50 为 1.6 μM。LabMol-319 是一种抗病毒活性分子。

GC68517 2-Hydroxy-4-methylbenzenesulphonic acid ammonium 2-Hydroxy-4-methylbenzenesulphonic acid ammonium 是 Policresulen 的杂质。 Policresulen 是一种有效的 NS2B/NS3 蛋白酶抑制剂，IC50 为 0.48 μg/mL。Policresulen 有效抑制 DENV2 病毒在 BHK-21 细胞中的复制，IC50 为 4.99 μg/mL。Policresulen 是蛋白酶的竞争性抑制剂，并轻微影响蛋白酶的稳定性。

GC65864 Policresulen

Policresulen 是一种有效的 DENV2 NS2B/NS3 蛋白酶抑制剂 (IC50 为 0.48 μg/mL)。Policresulen 抑制 BHK-21 细胞中的 DENV2 复制，IC50 为 4.99 μg/mL。Policresulen 作为蛋白酶的竞争性抑制剂，对蛋白酶的稳定性有轻微影响。

GC64368 Ensitrelvir fumarate An inhibitor of SARS-CoV-2 M^pro

GC64207 (+)-JNJ-A07 (+)-JNJ-A07 是一种靶向 NS3-NS4B 相互作用的高效泛血清型登革热病毒抑制剂。(+)-JNJ-A07 对 21 株临床分离株发挥纳摩尔到皮摩尔的活性。(+)-JNJ-A07 具有良好的药代动力学特征，在小鼠感染模型中对登革热病毒感染有显著疗效。

GC63882 L-Lysine-15N2 hydrochloride L-Lysine-15N2 hydrochloride 是 15N 标记的 L-Lysine hydrochloride。L-lysine hydrochloride 人类必需的氨基酸，具有多种益处，可用于疱疹的研究，并能增加钙吸收，减少糖尿病相关疾病和改善肠道健康。

GC62208 Mpro inhibitor N3 hemihydrate Mpro inhibitor N3 hemihydrate 是一种有效的 SARS-CoV-2 Mpro 抑制剂，对 SARS-CoV-2 的 EC50 为 16.77 μM。Mpro inhibitor N3 hemihydrate 特别抑制多种冠状病毒的 Mpro，包括 SARS-CoV 和 MERS-CoV。Mpro inhibitor N3 hemihydrate 对 HCoV-229E、FIPV 和 MHV-A59 的抑制，IC50 分别为 4.0 μM、8.8 μM 和 2.7 μM。

GC61878 A2ti-2 A2ti-2 是选择性的，低亲和力的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂，IC50 为 230 µM。A2ti-2 特异性破坏 A2 和 S100A10 之间的蛋白质相互作用。A2ti-2 可防止人乳头瘤病毒 16 型 (HPV16) 感染。

GC61668 (E)-3,4-Dimethoxycinnamic acid (E)-3,4-Dimethoxycinnamicacid是3,4-Dimethoxycinnamicacid的低活性异构体。3,4-Dimethoxycinnamicacid是从Securidacainappendiculata中提取和纯化的单体。3,4-Dimethoxycinnamicacid通过ROS介导的信号途径对L-02细胞发挥抗凋亡作用。

GC60546 A2ti-1 A2ti-1是选择性的，高亲和力的膜联蛋白A2/S100A10异四聚体(A2t)抑制剂，IC50为24μM。A2ti-1特异性破坏A2和S100A10之间的蛋白质相互作用。A2ti-1可防止人乳头瘤病毒16型(HPV16)感染。

GC60484 2-Phenylethanol Phenethyl alcohol (2-phenylethanol, 2-Phenylethyl alcohol, Benzeneethanol, Phenylethanol) is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.

GC60030 5-Hydroxytoluene-2,4-disulphonic acid diammonium 5-Hydroxytoluene-2,4-disulphonicaciddiammonium是Policresulen的杂质。Policresulen是一种有效的NS2B/NS3蛋白酶抑制剂，IC50为0.48μg/mL。Policresulen有效抑制DENV2病毒在BHK-21细胞中的复制，IC50为4.99μg/mL。Policresulen是蛋白酶的竞争性抑制剂，并轻微影响蛋白酶的稳定性。

GC60025 4-Hydroxy-2-methylbenzenesulfonic acid ammonium 4-Hydroxy-2-methylbenzenesulfonicacidammonium是Policresulen的杂质。Policresulen是一种有效的NS2B/NS3蛋白酶抑制剂，IC50为0.48μg/mL。Policresulen有效抑制DENV2病毒在BHK-21细胞中的复制，IC50为4.99μg/mL。Policresulen是蛋白酶的竞争性抑制剂，并轻微影响蛋白酶的稳定性。

GC39497 ML188 ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with IC50 of 1.5 μM. ML188 has antiviral activity.

GC50441 Rupintrivir Rupintrivirvr (AG7088) 是一种抗病毒药物，是一种强效、选择性和不可逆的人鼻病毒 (HRV) 3C 蛋白酶抑制剂。

GC38967 Lycorine An alkaloid with diverse biological activities

GC38677 (-)-α-Pinene (-)-α-Pinene 是一种单萜类化合物，通过在 BZD 结合位点作为部分调节剂与 GABAA-苯二氮卓 (BZD) 受体直接结合，显示出增强睡眠的特性。

GC38432 Dipotassium glycyrrhizinate Glycyrrhizinate dipotassium (Neubormitin) is a widely used anti-inflammatory agent isolated from the licorice root.

GC38312 Anthraquinone Anthraquinone 被用作染料形成的前体。

GC36884 PF429242 dihydrochloride A site-1 protease inhibitor

GC35306 alpha-Mangostin A xanthone with diverse biological activities

GC45099 U-0126

A MEK inhibitor and AMPK activator

GC41625 Oroxylin A A flavonoid with diverse biological activities

GC33992 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.

GC33055 NGI-1 (ML414) An OST inhibitor

GC32372 PCL 016 Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.

GC32201 2-Phenylethanol (Phenethyl alcohol) Phenethyl alcohol (2-phenylethanol, 2-Phenylethyl alcohol, Benzeneethanol, Phenylethanol) is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.

GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。

GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

GC30056 Danthron (Dantron) Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.