Proteasome
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
- Cat.No. Product Name Information
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GC41233
(R)-MG132
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins.
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GC10102
Aclacinomycin A
Topoisomerase I and II inhibitor
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GC35238
Aclacinomycin A hydrochloride
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
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GC33743
Alicapistat (ABT-957)
Alicapistat(ABT-957)是具有口服活性的,人钙激活中性蛋白酶(calpains)1和2的选择性抑制剂,有治疗阿尔兹海默症(AD)的潜能。
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GC13789
AM 114
20S proteasome inhibitor
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GC12784
Artemether (SM-224)
Semi-synthetic derivative of artemisinin
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GC17644
Bortezomib (PS-341)
Proteasome Inhibitor
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GC12527
Calpain Inhibitor I, ALLN
Calpain I/II/ B/L inhibitor
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GC10342
Calpeptin
Ca2+-dependent protease,calpain inhibitor
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GC32815
Capzimin
Capzimin是有效的,特异性适中的,蛋白酶体异肽酶Rpn11抑制剂。
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GC15089
Carfilzomib (PR-171)
Carfilzomib (PR-171)是一种不可逆proteasome抑制剂,在ANBL-6细胞中IC50为<5 nM,在体外优先抑制β5亚基的ChT-L活性,对PGPH和T-L活性很弱或没有作用。
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GC15083
Celastrol
Antioxidant, anti-inflammatory and immunosuppressive agent
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GC12272
CEP-18770
Proteasome inhibitor
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GC16581
Clasto-Lactacystin β-lactone
Proteasome inhibitor
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GC16747
Dihydroeponemycin
Proteasome inhibitor,antitumor reagent,eponemycin ddrivative
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GC12494
Epoxomicin
Proteasome inhibitor
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GC31563
FK-448 Free base
FK-448Freebase是一种有效的,特异性的糜蛋白酶(chymotrypsin)抑制剂,IC50值为720nM。
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GC13711
Gabexate mesylate
Trypsin-like serine proteinases inhibitor
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GC17255
Gliotoxin
20S proteasome inhibitor
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GC16699
HMB-Val-Ser-Leu-VE
inhibitor of the trypsin-like activity of the 20S proteasome