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Bromodomain

Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

  1. Cat.No. Product Name Information
  2. GC13822 (-)-JQ1

    BET bromodomain inhibitor

  3. GC46675 4-Phenyl-2-pyrrolidinone
  4. GC13014 AZD 5153 orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4.
  5. GC15175 BAZ2-ICR Selective BAZ2 bromodomain inhibitor
  6. GC16299 BET bromodomain inhibitor Potent and selective inhibitor for BRD4
  7. GC16726 BI-7273 BRD9 bromodomain inhibitor
  8. GC16817 BI-9564 BRD9/7 specific inhibitor
  9. GC16531 Bromodomain Inhibitor, (+)-JQ1 A BET bromodomain inhibitor
  10. GC10402 Bromosporine Bromodomain inhibitor,non-selective
  11. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs
  12. GC14699 CPI-203 BET bromodomain inhibitor
  13. GC43320 CPI-268456
  14. GC10382 CPI-637 CBP/EP300 bromodomain inhibitor
  15. GC10524 GSK 525768A inactive stereoisomer of I-BET-762
  16. GC12440 GSK 5959 BRPF1 bromodomain inhibitor
  17. GC14063 GSK1324726A BET proteins inhibitor
  18. GC15789 GSK2801 inhibitor of BAZ2A and BAZ2B bromodomains
  19. GC13025 GSK6853 BRPF1 inhibitor
  20. GC16611 GW841819X BET bromodomain inhibitor
  21. GC50070 I-BET 151 dihydrochloride BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
  22. GC13187 I-BET 151 hydrochloride BET bromodomain inhibitor
  23. GC17073 I-BET-762

    BET inhibitor,highly potent

  24. GC15747 I-BET151 (GSK1210151A) Selective BET inhibitor
  25. GC12588 I-BRD9 BRD9 inhibitor
  26. GC17944 I-CBP 112 CBP/EP300 bromodomain inhibitor
  27. GC43889 I-CBP112 (hydrochloride) cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.
  28. GC48548 iBET-BD2
  29. GC10727 Ischemin sodium salt CBP bromodomain inhibitor
  30. GC13148 MS436 BRD4 inhibitor
  31. GC16763 NI-57 bromodomains of BRPF proteins inhibitor
  32. GC17482 OF-1 BRPF1B and BRPF2 bromodomain inhibitor
  33. GC17973 OTX-015 BRD inhibitor
  34. GC14655 OXF BD 02 Selective inhibitor of the first bromodomain of BRD4
  35. GC15152 PF-CBP1 CBP/p300 bromodomain inhibitor
  36. GC14361 PFI 3 inhibitor of polybromo 1 and SMARCA4
  37. GC10979 PFI 4 Potent and selective BRPF1 Bromodomain inhibitor
  38. GC15375 PFI-1 (PF-6405761) BET inhibitor
  39. GC14199 RVX-208 Potent BET bromodomain inhibitor
  40. GC10174 SGC-CBP30 Inhibitor of CREBBP/EP300 bromodomain,potent
  41. GC48408 TW9
  42. GC14168 UMB-32 inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factor TAF1 and TAF1L
  43. GC16794 UNC1215 Chemical probe for the methyllysine (Kme)
  44. GC18096 UNC669 L3MBTL antagonist,potent and selective

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