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Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

  1. Cat.No. Product Name Information
  2. GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death
  3. GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
  4. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone 是从泰国著名的药用植物 Kaempferia parviflora (KP) 中分离出来的。5,7,4'-Trimethoxyflavone 诱导细胞凋亡,具体表现为增加了亚 G1 期,DNA 片段化,膜联蛋白 -V/PI 染色,Bax/Bcl-xL 比率,caspase-3 的蛋白水解活化,聚 (ADP-核糖) 聚合酶 (PARP) 蛋白的降解。5,7,4'-Trimethoxyflavone 以浓度依赖性方式显着有效抑制 SNU-16 人胃癌细胞的增殖。
  5. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist
  6. GC17602 Ac-DEVD-AFC fluorogenic substrate for activated caspase-3
  7. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO是一种特异性Caspase-3抑制剂,Ki值为230pM.
  8. GC10951 Ac-DEVD-CMK cell-permeable, and irreversible inhibitor of caspase
  9. GC60558 Ac-FLTD-CMK Ac-FLTD-CMK是胃泌素D(GSDMD)衍生的抑制剂,是炎症性caspases的特异性抑制剂。Ac-FLTD-CMK对caspases-1(IC50为46.7nM),caspases-4(IC50为1.49μM),caspases-5(IC50为329nM)和caspases-11均有效,但对凋亡相关的caspase-3无效。
  10. GC10258 Ac-IEPD-AFC Recognition motif for serine protease granzyme B
  11. GC10968 Ac-LEHD-AFC Fluorogenic caspase substrate
  12. GC14209 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable
  13. GC10160 Apoptosis Inhibitor

    Associate with caspase-3 inhibition

  14. GC35388 Aristolactam I Aristololactam I (AL-I) 是马兜铃酸I (AA-I) 的主要代谢产物,参与导致肾损伤的过程。Aristololactam I (AL-I) 直接损伤肾近端小管细胞,AL-I 的细胞毒性效力高于AA-I,并且这些分子的细胞毒性作用是通过 caspase-3 依赖性细胞凋亡介导。
  15. GC35395 Arnicolide D Arnicolide D 是一种从石胡荽 (Centipeda minima) 中分离出倍半萜内酯。Arnicolide D 调节细胞周期,激活 caspase 信号通路,并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。Arnicolide D 以剂量和时间依赖性方式显着抑制鼻咽癌 (NPC) 细胞生长。
  16. GC60603 Asperosaponin VI AsperosaponinVI是来自续断壁的一种皂苷组分。AsperosaponinVI通过BMP-2/p38和ERK1/2信号途径诱导成骨细胞分化。AsperosaponinVI通过增加Bcl-2/Bax比值,降低活性caspase-3表达,以及增强p-Akt和p-CREB,从而抑制缺氧诱导的心肌细胞凋亡(apoptosis)。
  17. GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  18. GC18476 Biotin-VAD-FMK Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK .
  19. GC16774 Boc-D-FMK Pan-caspase inhibitor
  20. GC11718 Caspase-3/7 Inhibitor I Caspase-3/7 inhibitor
  21. GC31886 Chelidonic acid Chelidonicacid是从ChelidoniummajusL.中分到的酸类物质,为一种温和镇痛剂、抗菌剂和中枢神经系统镇静剂。Chelidonicacid具有抗炎作用,可能通过抑制NF-κB和caspase-1来降低IL-6的产生。Chelidonicacid为glutamatedecarboxylase抑制剂,Ki值为1.2μM

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