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Patulin 目录号 GC40483

规格 价格 库存 购买数量
5mg
¥754.00
现货
10mg
¥1,430.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

Quality Control & SDS

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Chemical Properties

Cas No. 149-29-1 SDF Download SDF
别名 Clairformin, Expansin, Mycoin C, NSC 8120, NSC 32951
化学名 4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
Canonical SMILES O=C1OC2=CCOC(O)C2=C1
分子式 C7H6O4 分子量 154.1
溶解度 13mg/mL in ethanol, 10mg/mL in DMSO, 20mg/mL in DMF 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Patulin is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.[1] Patulin-induced nephropathy and gastrointestinal tract malfunction have been demonstrated in several animal models.[2] The oral LD50 value of patulin ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry.[1] The World Health Organization considers patulin cytotoxic and established a safety level of patulin in apple juice at 50 μM.2 At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells.[2] In 1944, this compound was tested in a clinical trial for potential antibiotic properties to treat the common cold.[3]

Reference:
[1]. Puel, O., Galtier, P., and Oswald, I.P. Biosynthesis and toxicological effects of patulin. Toxins 2(4), 613-631 (2010).
[2]. Liu, B.H., Wu, T.S., Yu, F.Y., et al. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicological Sciences 95(2), 340-347 (2007).
[3]. Chalmers, I., and Clarke, M. Commentary: The 1994 patulin trial: The first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int.J.Epidemiol. 32, 253-260 (2004).