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Micafungin sodium 目录号 GC17507

Inhibitor of β-(1,3)-D-glucan synthesis;fungicide

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥1,029.00
现货
5mg
¥504.00
现货
10mg
¥966.00
现货
25mg
¥2,069.00
现货
50mg
¥2,888.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

Quality Control & SDS

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实验参考方法

Fungus experiment [1]:

Fungi

Pseudomonas aeruginosa (P. Aeruginosa)

Preparation method

This compound is soluble in water. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reaction Conditions

10 mg/mL; 24 hrs

Applications

Micafungin decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively).

Animal experiment [2]:

Animal models

A mouse model of septic Aspergillus fumigatus (A. fumigatus) infection

Dosage form

0.1, 0.32 and 1 mg/kg; s.c.; q.d.

Applications

In a mouse model of septic A. fumigatus infection, Micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When Micafungin (0.1 mg/kg) was combined with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. For non-treated mice, they survived for only 6 days.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Bazzi W, Sabra A, Zahreddine L, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling, 2013, 29(8): 909-915.

[2]. Kai H, Yamashita M, Nakamura I, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigatus and its efficacy in murine infection models. J Antibiot (Tokyo), 2013, 66(8): 479-484.

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Chemical Properties

Cas No. 208538-73-2 SDF
别名 FK 463;Funguard;Mycamine
Canonical SMILES CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC(=C(C=C7)O)OS(=O)(=O)[O-])O)O)C(CC(=O)N)O)C)O)O)O.[Na+]
分子式 C56H70N9NaO23S 分子量 1292.26
溶解度 ≥64.66 mg/mL in DMSO, <2.35 mg/mL in EtOH, ≥17.5 mg/mL in H2O with ultrasonic and warming 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Micafungin is an antifungal agent [1].
Antifungal medicine is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively) [1].
In a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days [2].
References:
[1]. Bazzi W, Sabra A, Zahreddine L, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling, 2013, 29(8): 909-915.
[2]. Kai H, Yamashita M, Nakamura I, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigatus and its efficacy in murine infection models. J Antibiot (Tokyo), 2013, 66(8): 479-484.