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Methoxy-X04 目录号 GC10894

fluorescent amyloid β (Aβ) probe

规格 价格 库存 购买数量
1mg
¥325.00
现货
5mg
¥1,144.00
现货
10mg
¥1,794.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 863918-78-9 SDF
别名 N/A
化学名 4,4'-((1E,1'E)-(2-methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
Canonical SMILES COC1=C(C=CC(/C([H])=C([H])/C2=CC=C(O)C=C2)=C1)/C([H])=C([H])/C3=CC=C(O)C=C3
分子式 C23H20O3 分子量 344.4
溶解度 5 mg/ml in ethanol; 30 mg/ml in DMSO and DMF 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.[1],[2] For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.[2]

Reference:
[1]. Klunk, W.E., Backsai, B.J., Mathis, C.A., et al. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61(9), 797-805 (2002).
[2]. Burgold, S., Bittner, T., Dorostkar, M.M., et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta. Neuropathol. 121(3), 327-335 (2011).