Malic acid (E 296)
(Synonyms: DL-苹果酸; Hydroxybutanedioic acid; E 296) 目录号 : GC33608
The racemate of L-malic acid
Cas No.:6915-15-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
DL-Malic acid is the racemate of the metabolic intermediate L-malic acid.1 It reduces CCL2 and ICAM expression induced by IFN-γ and TNF-α in HaCaT human keratinocytes when used at a concentration of 1 mM.2 Topical administration of DL-malic acid (10 mM) inhibits epidermis and dermis thickening, as well as mast cell and eosinophil dermal infiltration in a mouse model of atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNBC). Formulations containing DL-malic acid have been used as food and cosmetic preservatives and acidity regulators.
1.Ryan, D.G., Murphy, M.P., Frezza, C., et al.Coupling Krebs cycle metabolites to signalling in immunity and cancerNat. Metab.116-33(2019) 2.Lee, B., Heo, J., Hong, S., et al.??-Malic acid as a component of α-hydroxy acids: Effect on 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in vitro and in vivoImmunopharmacol. Immunotoxicol.41(6)614-621(2019)
| Cas No. | 6915-15-7 | SDF | |
| 别名 | DL-苹果酸; Hydroxybutanedioic acid; E 296 | ||
| Canonical SMILES | O=C(O)C(O)CC(O)=O | ||
| 分子式 | C4H6O5 | 分子量 | 134.09 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.4577 mL | 37.2884 mL | 74.5768 mL |
| 5 mM | 1.4915 mL | 7.4577 mL | 14.9154 mL |
| 10 mM | 0.7458 mL | 3.7288 mL | 7.4577 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
A new deep eutectic solvent-agarose gel with hydroxylated fullerene as electrical "switch" system for drug release
Carbohydr Polym 2022 Nov 15;296:119939.PMID:36087988DOI:10.1016/j.carbpol.2022.119939
A novel portable conductive system of hydroxylated fullerene (TEGs-C60) embedded on the deep eutectic solvent (DES, choline chloride/Malic acid)-agarose gel was developed for on-demand curation with skin contact. It has been found with better elasticity, conductivity and thermal stability than agarose hydrogel. Especially, the electro-responsive drug releasing amount on the skin of mice and live rabbits through small batteries was proved to be 4-5 times of those without electrical stimulation, which reached the level of clinic daily dosage. Meanwhile, it also showed good biocompatibility and much higher antibacterial rate against S. aureus (78.67 ± 0.80 %) together with E. coli (92.08 ± 1.50 %) than those of commercial chitosan gel. The new electrical "switch" gel system provided an effective and useful development strategy for advanced drug delivery.