Hydroxyethyl cellulose (2-Hydroxyethyl cellulose)
(Synonyms: 羟乙基纤维素,2-Hydroxyethyl cellulose; Cellulose hydroxyethyl ether) 目录号 : GC30153
羟乙基纤维素（2-羟乙基纤维素）是一种非离子改性纤维素聚合物，用作水性化妆品和个人护理配方的增稠剂。
Cas No.:9004-62-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Hydroxyethyl cellulose is a non-ionic, water soluble, modified cellulose polymer used as a thickening agent for aqueous cosmetic and personal care formulations.
Stabilization of graphene oxide in physiological solution is performed using hydroxyethyl cellulose to make the resultant nanohybrid suitable for targeted drug delivery purposes. Hydroxyethyl cellulose effectively stabilizes graphene oxid in electrolyte solutions and the mechanism of stabilization appears to be depended on hydroxyethyl cellulose content. Hydroxyethyl cellulose content in the nanohybrid plays an important role in final application to make it applicable either as a carrier for controllable drug release or as a folate-targeted drug carrier[1]. Hydroxyethyl cellulose shows superior cryoprotective effects on LDH during freeze thawing, and considerable lyoprotective effects during the freeze drying process. Annealing has limited influence on the stabilizing effect of hydroxyethyl cellulose. The extensive reconstitution times of the hydroxyethyl cellulose lyophilisates could be greatly improved by incorporation of the surfactant Tween 80 into the formulations prior to freeze drying[2].
[1]. Mianehrow H, et al. Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application. Int J Pharm. 2015 Apr 30;484(1-2):276-82. [2]. Al-Hussein A, et al. Investigation of the stabilizing effects of hydroxyethyl cellulose on LDH during freeze drying and freeze thawing cycles. Pharm Dev Technol. 2015 Jan;20(1):50-9.
| Cas No. | 9004-62-0 | SDF | |
| 别名 | 羟乙基纤维素,2-Hydroxyethyl cellulose; Cellulose hydroxyethyl ether | ||
| Canonical SMILES | [Cellulose glycol] | ||
| 分子式 | 分子量 | ||
| 溶解度 | Water : 9.09 mg/mL (warming and heat to 93°C);DMSO : < 1 mg/mL (insoluble or slightly soluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Sonocatalytic degradation of 2-Hydroxyethyl cellulose in the presence of some nanoparticles
Ultrason Sonochem 2015 Sep;26:265-272.25637291 10.1016/j.ultsonch.2014.12.014
The degradation of 2-Hydroxyethyl cellulose (HEC) by means of ultrasound irradiation and its combination with heterogeneous catalysts such as TiO2 (Rutile and Anatase), Montmorillonite Clay (MMT), ZnO and Fe3O4 nanoparticles was investigated. The effect of the type and quantity of nanoparticles, the initial molecular weight of polymer and the different ultrasonic power have been studied. Degradation behavior of HEC was studied through FTIR, XRD and SEM techniques and kinetics of degradation was studied by viscometry. Also, reduce in molecular weight (Mw) of polymer was investigated by gel permeation chromatography (GPC) analysis. The results of experiments suggested that the sonocatalytic degradation of HEC were remarkably higher than sonolytic degradation. However, the catalytic activity of nanoparticles in contrast to the ultrasonic irradiation was different. The experimental results revealed that the best HEC degradation can be obtained when the added Fe3O4 amount was 0.4 g/L. Furthermore, kinetic analysis of the polymer degradation process was carried out in this study.
Nanocomposite Cryogel Carriers from 2-Hydroxyethyl cellulose Network and Cannabidiol-Loaded Polymeric Micelles for Sustained Topical Delivery
Polymers (Basel) 2020 May 20;12(5):1172.32443724 PMC7284876
In this contribution, we report the development of original nanocomposite cryogels for sustained topical delivery of hydrophobic natural active substances such as cannabidiol (CBD). The cryogels were fabricated by a method involving cryogenic treatment and photo-crosslinking of aqueous systems containing biodegradable 2-Hydroxyethyl cellulose (HEC) and CBD-loaded polymeric micelles. The preparation of the water-soluble form of CBD was a key element for the successful drug loading in the one-pot reaction. The main physical, mechanical and biological characteristics of CBD-loaded and blank cryogels such as gel fraction yield, swelling degree, morphology, storage and loss moduli, and cytotoxicity were studied in detail. The advantage of nanocomposite over pure HEC cryogel carriers in terms of achieving a sustained release profile was also demonstrated.
Solid polymer electrolyte production from 2-Hydroxyethyl cellulose: Effect of ammonium nitrate composition on its structural properties
Carbohydr Polym 2017 Jun 1;165:123-131.28363531 10.1016/j.carbpol.2017.02.033
Addition of doping materials can possibly enhance the ionic conduction of solid polymer electrolyte (SPE). In this work, a new SPE using 2-Hydroxyethyl cellulose (2-HEC) incorporated with different ammonium nitrate (NH4NO3) composition was prepared via solution casting method. Studies of structural properties were conducted to correlate the ionic conductivity of 2-HECNH4NO3 SPE using X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. Encouraging result was obtained as the ionic conductivity increased about two orders of magnitude upon addition of 12wt% of NH4NO3. XRD analysis shows the most amorphous SPE was obtained at 12-NH4NO3. From FTIR spectra, the interactions between 2-HEC and NH4NO3 were observed by the shifts of COH peak from 1355cm-1 to 1330cm-1 and the presence of new NH peak in the OH region. The spectrum has been validated theoretically using Gaussian software. The results obtained from this study corroborate that the complexes of 2-HEC and NH4NO3 responsible to promote the ionic conductivity to the higher value.
Electrophoretic determination of taurine
J Chromatogr A 2021 May 24;1645:462075.33848661 10.1016/j.chroma.2021.462075
An electrophoretic method (on-line coupled capillary isotachophoresis and capillary zone electrophoresis) with conductometric detection for the determination of free taurine in selected food and feed is described. Taurine is converted to isethionic acid by van Slyke method. Under optimized conditions (leading electrolyte: 5 mM HCl, 10 mM glycylglycine, and 0.05% 2-Hydroxyethyl cellulose solution, pH 3.2; terminating electrolyte: 10 mM citric acid; background electrolyte: 50 mM acetic acid, 20 mM glycylglycine, and 0.1% 2-Hydroxyethyl cellulose solution, pH 3.7), isethionic acid is separated from other sample components in anionic mode and detected using a conductimeter within 15 minutes. The performance method characteristics, such as linearity (25 - 1250 ng/mL), accuracy (99 ± 9%), repeatability (3.9%), reproducibility (4.3%), limits of detection (3 ng/mL) and quantification (10 ng/mL) were evaluated. By analysing 20 food and pet food samples the method was proved suitable for routine analysis. High sensitivity and selectivity, short analysis time and low costs are significant features of the presented method.
Preparation of Hydroxyethyl cellulose/halloysite nanotubes graft polylactic acid-based polyurethane bionanocomposites
Int J Biol Macromol 2020 Jun 15;153:591-599.32156538 10.1016/j.ijbiomac.2020.03.038
2-Hydroxyethyl cellulose graft polylactic acid copolymer (HLAC) was prepared by graft copolymerization of lactic acid (LA) and 2-Hydroxyethyl cellulose (2-HEC), initiated by dibutyltin dilaurate (DBTDL) catalyst in aqueous media. Halloysite nanotubes (HNTs)/polyurethane (PU) bionanocomposites were prepared using the HLAC as chain extender in the step-growth polymerization. HNTs were dispersed in HLAC based PU matrix at different weight ratios of 0.30, 0.50, 1.00, and 3.00. Chemical structure and morphology of the graft copolymer and bionanocomposite elastomers were characterized using solid state 1H NMR, ATR-FTIR, XRD, and SEM-EDX, while thermal degradation behavior was studied by TGA and DSC techniques. Surface morphology of the HNTs reinforced HLAC/PU bio-nanocomposites demonstrated the homogeneous dispersion of HNTs with little wavy rough surface at low contents which turned to be brittle at higher contents due to agglomerated HNTs. It is observed that the lower contents of HNTs were completely exfoliated in the HLAC/PU matrix. Crystalline pattern of the elastomers improved at lower contents of HNTs that enhanced the thermal stability of the bionanocomposites. The mechanical testing suggested that HNTs/HLAC/PU bionanocomposites have higher values of tensile strength and % elongation with only 0.3-0.5 wt% contents of HNTs that suggested the potential applications of elastomers at economic cost.