(E/Z)-Polydatin
(Synonyms: (E/Z)-虎杖苷; (E/Z)-Piceid) 目录号 : GC38965
A stilbene glucoside with diverse biological activities
Cas No.:65914-17-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside is a stilbene glucoside that has been found in V. vinifera and has diverse biological activities.1,2,3,4,5 It reduces the growth of SKOV3 ovarian cancer cell 3D aggregates in a concentration-dependent manner.2 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (10 and 20 ?g/ml) inhibits IL-17 production in activated peripheral blood mononuclear cells (PBMCs).3 It inhibits the loss of glutathione peroxidase 4 (GPX4) activity induced by the ferroptosis inducer hemin in Neuro2a neuroblastoma cells.4 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (50 mg/kg) reduces escape latency in a rat model of vascular dementia induced by four-vessel occlusion (4-VO).5
1.Teguo, P.W., Fauconneau, B., Deffieux, G., et al.Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell culturesJ. Nat. Prod.61(5)655-677(1998) 2.Hogg, S.J., Chitcholtan, K., Hassan, W., et al.Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell linesObstet. Gynecol. Int.279591(2015) 3.Lanzilli, G., Cottarelli, A., Nicotera, G., et al.Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulationInflammation35(1)240-248(2012) 4.Huang, L., He, S., Cai, Q., et al.Polydatin alleviates traumatic brain injury: Role of inhibiting ferroptosisBiochem. Biophys. Res. Commun.556149-155(2021) 5.Li, R.-P., Wang, Z.-Z., Sun, M.-X., et al.Polydatin protects learning and memory impairments in a rat model of vascular dementiaPhytomedicine19(8-9)677-681(2012)
| Cas No. | 65914-17-2 | SDF | |
| 别名 | (E/Z)-虎杖苷; (E/Z)-Piceid | ||
| Canonical SMILES | O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC(/C=C/C3=CC=C(O)C=C3)=CC(O)=C2 | ||
| 分子式 | C20H22O8 | 分子量 | 390.38 |
| 溶解度 | DMSO: 150 mg/mL (384.24 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5616 mL | 12.808 mL | 25.6161 mL |
| 5 mM | 0.5123 mL | 2.5616 mL | 5.1232 mL |
| 10 mM | 0.2562 mL | 1.2808 mL | 2.5616 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。