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Arachidonoyl 2'-Chloroethylamide 目录号 GC18435

A potent and selective CB1 receptor agonist

规格 价格 库存 购买数量
5mg
¥364.00
现货
10mg
¥689.00
现货
25mg
¥1,638.00
现货
50mg
¥2,912.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 220556-69-4 SDF Download SDF
别名 ACEA, 2'-chloro-AEA
化学名 N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Canonical SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCCl
分子式 C22H36ClNO 分子量 366
溶解度 25mg/mL in ethanol, 20mg/mL in DMSO, 30mg/mL in DMF 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

References:
[1].Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8), 635-664 (1999).
[2].Hillard, C.J., Manna, S., Greenberg, M.J., et al. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1) J. Pharmacol. Exp. Ther. 289(3), 1427-1433 (1999).