|A23187 (calcium magnesium salt) 目录号 GC42659|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||N/A||SDF||Download SDF|
|化学名||5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid, calcium salt (2:1) 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(|
|分子式||[C29H36N3O6]2 Ca •[C29H36N3O6]2 Mg||分子量||523.6|
|溶解度||3mg/mL in ethanol or DMF||储存条件||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways. A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.,
. Sullivan, T.J., and Parker, C.W. Pharmacologic modulation of inflammatory mediator release by rat mast cells. Am. J. Pathol. 85(2), 437-464 (1976).
. Maecker, H.T., Hedjbeli, S., Alzona, M., et al. Comparison of apoptosis signaling through T cell receptor, Fas, and calcium ionophore. Exp. Cell Res. 222(1), 95-102 (1996).
. Cho, S.Y., Lee, J.H., Bae, H.D., et al. Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of Bax. Exp. Mol. Med. 42(9), 639-650 (2010).