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α-Humulene 目录号 GC40262

α-Humulene is a sesquiterpene that has been found in C.

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Sample solution is provided at 25 µL, 10mM.


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Chemical Properties

Cas No. 6753-98-6 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES C/C1=C\CC/C(C)=C/CC(C)(C)/C=C/C1
分子式 C15H24 分子量 204.4
溶解度 Methanol: 10 mg/ml 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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α-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities. It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively). α-Humulene reduces growth of MCF-7 breast cancer cells by approximately 50% when used at a concentration of 32 mg/ml. It also reduces viability of Caco-2 cells in a concentration-dependent manner (IC50 = 24.4 mg/ml) but has no effect on viability of rat hepatocytes. In vivo, α-humulene (50 mg/kg) reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-α and IL-1β production and paw edema in mice and rats. It also reduces carrageenan-induced production of prostaglandin E2 (PGE2) and expression of inducible nitric oxide synthase (iNOS) and COX-2 in rats.