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Vincristine-d3

(Synonyms: Kyocristine-d3,Leurocristine-d3,Lilly 37231-d3,Novopharm-d3,VCR-d3) 目录号 : GC91505

Vincristine-d3 is intended for use as an internal standard for the quantification of vincristine by GC- or LC-MS.

Vincristine-d3 Chemical Structure

Cas No.:1246817-09-3

规格 价格 库存 购买数量
1 mg
¥5,026.00
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Sample solution is provided at 25 µL, 10mM.

Description

Vincristine-d3 is intended for use as an internal standard for the quantification of vincristine by GC- or LC-MS. Vincristine is a vinca alkaloid that has been found in C. rosea and has anticancer activities.[1],[2] It inhibits tubulin polymerization in a cell-free assay (Ki = 0.085 µM) and induces mitotic arrest in U937 cells when used at a concentration of 10 nM. In vivo, vincristine (3 mg/kg) reduces tumor growth in rhabdomyosarcoma patient-derived xenograft (PDX) mouse models.[3] Formulations containing vincristine have been used in the treatment of various cancers.

References:
[1].Jordan, M.A., Himes, R.H., and Wilson, L.Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitroCancer Res.45(6)2741-2747(1985).
[2].Towle, M.J., Salvato, K.A., Wels, B.F., et al.Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditionsCancer Res.71(2)496-505(2011).
[3].Horton, J.K., Houghton, P.J., and Houghton, J.A.Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenograftsBiochem. Pharmacol.37(20)3995-4000(1988).

化学性质

Cas No. 1246817-09-3 SDF Download SDF
别名 Kyocristine-d3,Leurocristine-d3,Lilly 37231-d3,Novopharm-d3,VCR-d3
分子式 C46H53D3N4O10 分子量 828
溶解度 Acetonitrile: soluble,DMSO: soluble,Methanol: soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2077 mL 6.0386 mL 12.0773 mL
5 mM 0.2415 mL 1.2077 mL 2.4155 mL
10 mM 0.1208 mL 0.6039 mL 1.2077 mL
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