Vincristine-d3
(Synonyms: Kyocristine-d3,Leurocristine-d3,Lilly 37231-d3,Novopharm-d3,VCR-d3) 目录号 : GC91505Vincristine-d3 is intended for use as an internal standard for the quantification of vincristine by GC- or LC-MS.
Cas No.:1246817-09-3
Sample solution is provided at 25 µL, 10mM.
Vincristine-d3 is intended for use as an internal standard for the quantification of vincristine by GC- or LC-MS. Vincristine is a vinca alkaloid that has been found in C. rosea and has anticancer activities.[1],[2] It inhibits tubulin polymerization in a cell-free assay (Ki = 0.085 µM) and induces mitotic arrest in U937 cells when used at a concentration of 10 nM. In vivo, vincristine (3 mg/kg) reduces tumor growth in rhabdomyosarcoma patient-derived xenograft (PDX) mouse models.[3] Formulations containing vincristine have been used in the treatment of various cancers.
References:
[1].Jordan, M.A., Himes, R.H., and Wilson, L.Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitroCancer Res.45(6)2741-2747(1985).
[2].Towle, M.J., Salvato, K.A., Wels, B.F., et al.Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditionsCancer Res.71(2)496-505(2011).
[3].Horton, J.K., Houghton, P.J., and Houghton, J.A.Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenograftsBiochem. Pharmacol.37(20)3995-4000(1988).
Cas No. | 1246817-09-3 | SDF | Download SDF |
别名 | Kyocristine-d3,Leurocristine-d3,Lilly 37231-d3,Novopharm-d3,VCR-d3 | ||
分子式 | C46H53D3N4O10 | 分子量 | 828 |
溶解度 | Acetonitrile: soluble,DMSO: soluble,Methanol: soluble | 储存条件 | -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.2077 mL | 6.0386 mL | 12.0773 mL |
5 mM | 0.2415 mL | 1.2077 mL | 2.4155 mL |
10 mM | 0.1208 mL | 0.6039 mL | 1.2077 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet