Tylvalosin tartrate
(Synonyms: 酒石酸乙酰异戊酰泰乐菌素,Acetylisovaleryltylo?sin tartrate) 目录号 : GC61363
A macrolide antibiotic
Cas No.:63428-13-7
Sample solution is provided at 25 µL, 10mM.
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Assay: >800u/mg
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Tylvalosin is a macrolide antibiotic.1 It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 ?g/ml, respectively). Tylvalosin (5 and 10 ?g/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 , and nitric oxide in RAW 264.7 cells.2 It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water.3 Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.
1.Yang, B., Lei, Z., Zhao, Y., et al.Combination susceptibility testing of common antimicrobials in vitro and the effects of sub-MIC of antimicrobials on Staphylococcus aureus biofilm formationFront. Microbiol.82125(2017) 2.Zhao, Z., Tang, X., Zhao, X., et al.Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activationBiochem. Pharmacol.90(1)73-87(2014) 3.Lopez Rodriguez, A., Berge, A.C., Ramage, C., et al.Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigsPorcine Health Manag.6(1)39(2020)
| Cas No. | 63428-13-7 | SDF | |
| 别名 | 酒石酸乙酰异戊酰泰乐菌素,Acetylisovaleryltylo?sin tartrate | ||
| Canonical SMILES | OC([C@H](O)[C@@H](O)C(O)=O)=O.O[C@@H]1[C@@H](C)O[C@@H](OC[C@H]([C@@H](CC)OC(C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]4C)=O)/C=C(C)/C=C/C4=O)[C@H](OC)[C@@H]1OC | ||
| 分子式 | C57H93NO25 | 分子量 | 1192.34 |
| 溶解度 | DMSO: 100 mg/mL (83.87 mM) | 储存条件 | -20°C, stored under nitrogen |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.8387 mL | 4.1934 mL | 8.3869 mL |
| 5 mM | 0.1677 mL | 0.8387 mL | 1.6774 mL |
| 10 mM | 0.0839 mL | 0.4193 mL | 0.8387 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Tylvalosin tartrate Improves the Health Status of Swine Herds during Immunization with Porcine Reproductive and Respiratory Syndrome Virus-Inactivated Vaccine
Vet Sci 2022 Dec 25;10(1):12.PMID:36669013DOI:10.3390/vetsci10010012.
Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease that affects pigs and is responsible for severe economic losses. The commercial PRRSV-inactivated vaccine (CH-1a strain) in China was recently selected to control PRRS in large populations of PRRS-positive sows and was found to effectively reduce the rate of stillbirth abortion based on clinical observations. However, stress from vaccine inoculation (e.g., fever, anorexia, abortions, and slow body weight gain) usually appears after immunization on many swine farms. In this study, we fed piglets a diet medicated with Tylvalosin tartrate during PRRSV-inactivated vaccine immunization. We found that Tylvalosin tartrate attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI. There was also attenuation in the intensity of the inflammatory response induced by vaccination and elevation of serum IFN-γ concentrations at three and seven DPI after immunization. The administration of Tylvalosin tartrate could also attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI. These results demonstrated that in addition to Tylvalosin tartrate being able to control respiratory and enteric bacterial infections in swine farms, it can also improve the stress status of swine herds during PRRSV-inactivated vaccine immunization.