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Tolazamide (U-17835) Sale

(Synonyms: 甲磺氮草脲; U-17835) 目录号 : GC32400

A sulfonylurea inhibitor of SUR1/KIR6.2

Tolazamide (U-17835) Chemical Structure

Cas No.:1156-19-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥620.00
现货
10mg
¥564.00
现货
50mg
¥2,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 ?M in HEK293 cells transfected with the human receptor).1 It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin.2 In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin .3 Formulations containing tolazamide have been used in the treatment of type 2 diabetes.

1.Gopalakrishnan, M., Molinari, E.J., Char-Change, S., et al.Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK-293 cellsBr. J. Pharmacol.129(7)1323-1332(2000) 2.Wang, P.H., Moeller, D., Flier, J.S., et al.Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cellsJ. Clin. Invest.84(1)62-67(1989) 3.Biederman, J.I., Vera, E., Rankhaniya, R., et al.Effects of sulfonylureas, α-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetesKidney Int.67(2)554-565(2005)

Chemical Properties

Cas No. 1156-19-0 SDF
别名 甲磺氮草脲; U-17835
Canonical SMILES O=S(C1=CC=C(C)C=C1)(NC(NN2CCCCCC2)=O)=O
分子式 C14H21N3O3S 分子量 311.4
溶解度 DMSO : ≥ 39 mg/mL (125.24 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.2113 mL 16.0565 mL 32.113 mL
5 mM 0.6423 mL 3.2113 mL 6.4226 mL
10 mM 0.3211 mL 1.6057 mL 3.2113 mL
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Research Update

Tolazamide

PMID:30000177DOI:NBK501118

Because no information is available on the use of Tolazamide during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]