Sodium tetraborate
目录号 : GC20104
Assay Standard
Cas No.:1330-43-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
| Cas No. | 1330-43-4 | SDF | |
| 分子式 | B4Na2O7 | 分子量 | 201.22 |
| 溶解度 | 储存条件 | Store at RT | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.9697 mL | 24.8484 mL | 49.6968 mL |
| 5 mM | 0.9939 mL | 4.9697 mL | 9.9394 mL |
| 10 mM | 0.497 mL | 2.4848 mL | 4.9697 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Sodium tetraborate simultaneously enhances the degradation of acetaminophen and reduces the formation potential of chlorinated by-products with heat-activated peroxymonosulfate oxidation
Water Res 2022 Oct 1;224:119095.PMID:36126631DOI:10.1016/j.watres.2022.119095.
In this study, Sodium tetraborate (Na2B4O7) was introduced to enhance the degradation of acetaminophen (ACT) in heat-activated peroxymonosulfate (PMS) process. The elimination of ACT in Na2B4O7/heat/PMS process followed the pseudo-first order kinetics. The corresponding kobs value with 10 mM Na2B4O7 was 33.1 times higher than that in heat/PMS process. 1O2 and HO· were identified as primary reactive species via quenching experiments and electron paramagnetic resonance technology. B(OH)4-, the hydrolysis product of Na2B4O7, reacted with PMS to generate HOOB(OH)3-. 1O2 was generated by the self-decomposition of PMS using B(OH)4- as catalyst, while HO· was produced via the breakage of peroxide bond of PMS and HOOB(OH)3-under high temperature. ACT was degraded by reactive species via the pathways of -NH- bond breakage, -OH replacement, -NH2 oxidation and benzene ring cleavage. Nine transformation intermediates were detected by LC/Q-TOF/MS, and the toxicity of reaction solution decreased significantly with the elimination of ACT. Increasing Na2B4O7 dosage, PMS concentration, initial pH and reaction temperature were conducive to ACT elimination. Humic acid, Cl- and CO32- inhibited the degradation of ACT heavily, while SO42- and NO3- had the negligible effects. Moreover, B(OH)4- could react with free chlorine to the inert B(OH)3OCl- and further significantly suppress the formation of chlorinated by-products for the treatment of Cl--containing water in Na2B4O7/heat/PMS process. This study provided an effective way to enhance the oxidation capacity of heat/PMS process and suppress the formation of chlorinated by-products in chloride-containing water, and the findings had important implications for using borate buffer in the studies of PMS-based advanced oxidation processes.
Data on Sodium tetraborate as a modulation of hypertrophic intracellular signals
Data Brief 2021 Feb 18;35:106889.PMID:33850976DOI:10.1016/j.dib.2021.106889.
The present work benefits the use of Sodium tetraborate to prevent and treat hypertrophic cardiac. The data obtained from the work could serve as a reference point to compare with data obtained in vivo studies with cardiac damage. This research will be an advantage for future researches to stimulate the ones focused on developing food supplements to prevent heart diseases such as cardiac hypertrophic. This article also indicates the data on the optimal concentration of isoproterenol as an inducer of hypertrophy in cardiomyocytes. Also, data of the cytotoxic effect of Sodium tetraborate on normal cardiomyocytes is revealed. Finally, data of viability, cell size, proliferation nuclear antigen (PCNA) and apoptosis is shown. The expression of transcription factors linked to hypertrophy such as GATA-4, MEF2c, NFAT, CDk9, and myogenin was also quantified by immunofluorescence. The mRNA expression of adrenergic receptors (alpha and beta), AKT1 and Erk1 / 2 and genes of early response to hypertrophy (c-myc, c-fos, c-jun) are also shown as Cts of RT-qPCR. GAPDH and 18 s were used as housekeeping genes.
Role of Sodium tetraborate as a cardioprotective or competitive agent: Modulation of hypertrophic intracellular signals
J Trace Elem Med Biol 2020 Dec;62:126569.PMID:32563862DOI:10.1016/j.jtemb.2020.126569.
Boron is an essential trace element in cellular metabolism; however, the molecular mechanism of boron in the heart is unclear. In this study, we examined the effect of Sodium tetraborate (as boron source) as a possible protective agent or competitive inhibitor of cardiac hypertrophy in an in vitro murine model. We evaluated different previously reported Sodium tetraborate concentrations and it was found that 13 μM improves viability without affecting the cellular structure. We demonstrated that cardiomyocytes pretreated with Sodium tetraborate prevents cellular damage induced by isoproterenol (cardioprotective effect) by increasing proliferation rate and inhibiting apoptosis. In addition, the reduction of the expression of the α1AR and β1AR adrenergic receptors as well as Erk1/2 was notable. Consequently, the expression of the early response genes c-myc, c-fos and c-jun was delayed. Also, the expression of GATA-4, NFAT, NKx2.5 and myogenin transcription factors involved in sarcomere synthesis declined. In contrast, cardiomyocytes, when treated simultaneously with Sodium tetraborate and isoproterenol, did not increase their size (cytoplasmic gain), but an increase in apoptosis levels was observed; therefore, the proliferation rate was reduced. Although the mRNA levels of α1AR and β1AR as well as Erk1/2 and Akt1 were low at 24 h, their expression increased to 48 h. Notably, the mRNA of expression levels of c-myc, c-fos and c-jun were lower than those determined in the control, while the transcription factors GATA-4, MEF2c, Nkx2.5, NFAT and CDk9 were determined in most cells. These results suggest that pretreatment with Sodium tetraborate in cardiomyocytes inhibits the hypertrophic effect. However, Sodium tetraborate attenuates isoproterenol induced hypertrophy damage in cardiomyocytes when these two compounds are added simultaneously.
A 3D printable, highly stretchable, self-healing hydrogel-based sensor based on polyvinyl alcohol/Sodium tetraborate/sodium alginate for human motion monitoring
Int J Biol Macromol 2022 Oct 31;219:1216-1226.PMID:36058388DOI:10.1016/j.ijbiomac.2022.08.175.
Self-healing hydrogels have great application potential in the field of bio-sensors due to their self-healing, flexibility and excellent tensile properties. However, most hydrogel-based sensors are processed by template method, which is unable to fabricate complex three-dimensional (3D) structures, and limits the development of hydrogel-based sensor devices. A simple yet efficient one-pot method was proposed to fabricate polyvinyl alcohol/Sodium tetraborate/sodium alginate hydrogel inks (SPB), also a fabricating process of self-healing hydrogel based on 3D printing technology has been proposed. The SPB hydrogel rapidly healed (<30 s) at room temperature, while its mechanical properties and conductivity also recovered quickly after healing. Besides, it could be used as wearable strain sensors, whose high stretchability (>2800 % strain) and sensitivity (gauge factor: 18.56 at 2000 % strain) could not only detect very large stretch deformations, but also detect the tiny pressure changes in the human body, such as finger flexion, knee flexion, and respiration. This study provides a method for the rapid fabrication of complex-structured hydrogel-based sensors, which is helpful for the hydrogel-based sensor applications in human motion detection and wearable devices.
Sodium tetraborate effects on mortality and reproduction of Anastrepha suspensa (Diptera: Tephritidae)
J Econ Entomol 2000 Oct;93(5):1485-92.PMID:11057722DOI:10.1603/0022-0493-93.5.1485.
When flies were treated with 0- 0.5% Sodium tetraborate by feeding for 24 h, mortality in treatments was not different from controls. Fecundity and fertility were reduced by 0.5% Sodium tetraborate. When flies were fed for 48 h, mortality of both males and females increased in the 0.5% Sodium tetraborate treatment; oviposition was eliminated for 20 d after treatment. When treatment was extended to 168 h, 0.1% Sodium tetraborate caused increased mortality and decreased fecundity and fertility. Fed for 168 h, 0.2 and 0.5% Sodium tetraborate killed almost all flies within the 7-d treatment. Oviposition of survivors in 0.1 and 0.2% Sodium tetraborate treatments was arrested for 20 d after treatment.