Sodium diatrizoate (Diatrizoic acid sodium salt)
(Synonyms: 泛影酸钠; Diatrizoic acid sodium salt; Sodium amidotrizoate) 目录号 : GC30201
Diatrizoate sodium (Amidotrizoate sodium, Hypaque sodium, Triombrin) is an iodinated radiopaque X-ray contrast medium that is used as a diagnostic aid in angiography, urography and radiography.
Cas No.:737-31-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Animal experiment: | Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Sodium diatrizoate nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1]. |
References: [1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12. | |
Diatrizoate sodium (Amidotrizoate sodium, Hypaque sodium, Triombrin) is an iodinated radiopaque X-ray contrast medium that is used as a diagnostic aid in angiography, urography and radiography.
| Cas No. | 737-31-5 | SDF | |
| 别名 | 泛影酸钠; Diatrizoic acid sodium salt; Sodium amidotrizoate | ||
| Canonical SMILES | O=C([O-])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.[Na+] | ||
| 分子式 | C11H8I3N2NaO4 | 分子量 | 635.9 |
| 溶解度 | DMSO : 100 mg/mL (157.26 mM);Water : ≥ 50 mg/mL (78.63 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5726 mL | 7.8629 mL | 15.7257 mL |
| 5 mM | 0.3145 mL | 1.5726 mL | 3.1451 mL |
| 10 mM | 0.1573 mL | 0.7863 mL | 1.5726 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The Complex Solid-State Landscape of Sodium diatrizoate Hydrates
Chemistry 2017 Dec 6;23(68):17339-17347.29044709 10.1002/chem.201703658
Pharmaceutical sodium salts are prone to incorporate water into their crystal structures. The model compound diatrizoic acid monosodium salt, an X-ray contrast agent, has been investigated in depth towards its interaction with water in the solid state. Five hydrates with water content ranging from 0.3 to 8 molar equivalents of water show a high degree of interconvertibility, stoichiometric and non-stoichiometric behaviour, and potential of amorphisation during release of water. A DMSO/water mixed solvate further highlights the high attraction of this salt to incorporate water. All incorporated solvent coordinates to the sodium cation and can further interact and stabilise the respective crystal forms by hydrogen bonding. DTS thus highlights the importance of an in-depth investigation of sodium salts used pharmaceutically to guarantee dose uniformity and stability of final formulation.
A novel flotation technique for the separation of nonadherent micro-organisms from a substrate
Lett Appl Microbiol 2014 Jun;58(6):604-9.24527951 10.1111/lam.12234
An understanding of adherence ability is crucial in many areas, for example, in research on biofilms, evaluation of probiotics or in biotechnology. In all these analyses, the reproducible washing is very important in the prevention of false results. During washing, the force, direction of the flow, position of the pipette tip, number of washing cycles, type of washing solution and the way of removing the washing solution can be sources of inappropriate stress to attached cells. To overcome these problems, we here propose the use of high mass density solutions as flotation agents. As the density of bacteria is lower than that of the flotation solutions, nonattached or weakly attached bacteria are moved to the surface due to hydrostatic force. Caesium chloride, ammonium nitrate and Sodium diatrizoate solutions, which are commonly used as FAs, were compared with a standard method of rinsing. Several concentrations of agents were used to investigate the optimal concentration and influence of hydrostatic pressure on adhered micro-organisms. We show that flotation is a rapid method for distinguishing between adhered and weakly attached or loosed cells with reproducible results. Due to its range of possible mass density concentration, the best FA was shown to be caesium chloride. Significance and impact of the study: This is the first study that suggests using flotation agents to separate planktonic from adhered bacteria. When a high-density solution is used, buoyancy of bacteria ensures their segregation in the solution. Flotation agents could be used instead of washing procedure, which is inaccurate and hardly reproducible. High-density flotation agents could be used for more precise evaluation of bacterial adherence in many assays, such as research of biofilms or evaluation of probiotics.
Spreading depression and the blood-brain barrier
Braz J Med Biol Res 1984;17(3-4):265-70.6529611
The propagation of spreading cortical depression was studied in rabbits during the reversible opening of the blood-brain barrier induced by hypertonic aqueous solutions of sodium chloride and Sodium diatrizoate. The rupture of the blood-brain barrier was monitored by the leakage of Evans blue-albumin from pial vessels. Spreading depression was monitored by recording its characteristic slow voltage variations. Test substances were injected into the carotid artery or topically applied to the pia-arachnoid surface. Intracarotid injection of hypertonic solutions that open the blood-brain barrier do not block the propagation of spreading depression. Topical application of NaCl solutions can block the spread of the cortical depression reaction without opening the blood-brain barrier. Recurrent spreading depression waves at a mean frequency of one every 5 min, for 4 h do not cause the release of Evans blue-albumin complex from pial vessels.
Trapped plasma vs. osmolality in canine microcapillary hematocrits
Invest Radiol 1983 Nov-Dec;18(6):526-9.6642949 10.1097/00004424-198311000-00009
The trapped plasma in the packed red cell portion of the microcapillary hematocrit of hypertonic canine blood was measured with I-125 labelled albumin. Blood osmolalities were raised by the addition of sodium chloride and meglumine/Sodium diatrizoate. The trapped plasma was 1.12 +/- 0.15%, 1.75 +/- 0.27% and 1.77 +/- 0.22% at 300, 580, and 723 mOsm/kg, respectively, for sodium chloride solutions. At 924 mOsm/kg some of the blood plus sodium chloride samples hemolyzed. In the group without hemolysis the trapped plasma was 5.84 +/- 1.35% while in the group with hemolysis it measured 12.43 +/- 1.90%. The trapped plasma with diatrizoate solutions was 1.41 +/- 0.11, 2.15 +/- 0.18 and 5.32 +/- 0.56 at 458, 531 and 602 mOsm/kg, respectively. Above an osmolality of 458 mOsm/kg the trapped plasma was significantly greater for the diatrizoate solutions than for the sodium chloride solutions. At osmolalities below 458 mOsm/kg only a small correction is needed for trapped plasma with either sodium chloride or meglumine/Sodium diatrizoate solutions.
Local and systemic effects of water-soluble contrast media and barium in rats with chronic small bowel obstruction
Invest Radiol 1995 Nov;30(11):683-9.8557509 10.1097/00004424-199511000-00008
Rationale and objectives: The local effects on the small intestine and systemic changes produced by different contrast media in small bowel obstruction, with time courses of 4 days, were evaluated. Materials and methods: Four groups, each with 10 normal rats and another four groups (also each with 10 rats) that had ligation of the terminal ileum (obstructed rats) for 4 days were given 3 mL of barium, meglumine Sodium diatrizoate, iohexol, or saline (control animals). Radiographs were taken immediately, 1 and 4 hours after administration of contrast media. Immediately before sacrifice, blood samples were taken to determine the hematocrit (Hct), hemoglobin (Hb), white blood cell count (WBC), red blood cell count (RBC), and serum sodium, and potassium and chloride concentrations. Specimens of small bowel were taken for histologic and morphometric analysis. Results: In obstructed rats, the image quality with iohexol improved on final radiographs despite being diluted in the great intestinal contents. There was an improvement in the serum electrolyte concentrations in the obstructed animals that were given any one of the contrast media, the best improvement being in the iohexol groups. A shortening of the length of epithelial cells when any one of the contrast media was administered was observed, as was an increase in the lymphatic space area in the diatrizoate group in normal rats. In the bowel proximal to the obstruction, the lymphatic space area was increased in the diatrizoate group and the size of the epithelial cells was higher in the diatrizoate and iohexol groups compared to the barium and saline groups. Conclusion: Our results suggest that iohexol offers good radiologic efficacy and excellent systemic and local tolerance in small bowel obstruction.