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SIN-1 chloride

(Synonyms: 5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐,Linsidomine) 目录号 : GC13152

SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation.

SIN-1 chloride Chemical Structure

Cas No.:16142-27-1

规格 价格 库存 购买数量
10mg
¥444.00
现货
50mg
¥1,840.00
现货
100mg
¥2,808.00
现货
500mg
¥12,864.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.

SIN-1 (chloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the SIN-1 (chloride) inan organic solvent. SIN-1 (chloride) is soluble in organic solvents such as cthanol, DMSO, and dimethyl formamidc. Thesolubility of SIN-1 (chloride) in these solvents is approximately 5 mg/ml.

Further dilutions of the stock solution into aqucous buffers or isotonic saline should be made prior to performingbiological experimcnts. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may havcephysiological effects at low concentrations. Organic solvent-free aqucous solutions of SIN-1 (chloride) can be preparedby directly dissolving the crystalline compound in aqucous buffers. The solubility of SIN-1 (chloridc) in PBS (pH 7.2) isapproximately 10 mg/ml. We do not recommend storing the aqucous solution for more than one day.

As the active mctabolite of molsidominc, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggrcgationIt produces both NO and superoxide and can therefore be used to gencrate peroxynitrite under physiological conditions.1-3

WARNING This product is not for human or veterinary use.


References:
1.Rosenkranz, B, Winkelmann, B.R., and Parnham, M.J. Clinical pharmacokinctics of molsidomine. Clin. Pharmokinet.30,372-384(1996).

2.Lomonosova, E.E, Kirsch, M, Rauen, U, et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus2.hydrogen peroxidc. Free Radic. Biol Med. 24, 522-528 (1998).

3.Nishikawa, M., Kanamori, M., and Hidaka, H. Inhibition of platelet aggregation and stimulation of guanylate cyclascby an antianginal agent molsidomine and its metabolites. J. Pharmacol. Exp. Ther. 220, 183-190 (1982).

Chemical Properties

Cas No. 16142-27-1 SDF
别名 5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐,Linsidomine
化学名 5-imino-3-morpholino-5H-1,2,3-oxadiazol-3-ium-2-ide hydrochloride
Canonical SMILES N=C1C=N(N2CCOCC2)=NO1.Cl
分子式 C6H11ClN4O2 分子量 206.63
溶解度 >9 mg/ml in DMSO, >5 mg/ml in DMF, >8 mg/ml in Ethanol 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.8396 mL 24.1978 mL 48.3957 mL
5 mM 0.9679 mL 4.8396 mL 9.6791 mL
10 mM 0.484 mL 2.4198 mL 4.8396 mL
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