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SE 175 Sale

目录号 : GC16204

A nitric oxide donor intended for in vivo use

SE 175 Chemical Structure

Cas No.:258278-64-7

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5mg
¥809.00
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10mg
¥1,507.00
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50mg
¥6,329.00
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100mg
¥11,056.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

SE 175 is a NO donor.

Nitric oxide (NO) mediates various physiological and pathophysiological processes in the cardiovascular system. Pharmacological compounds releasing NO are useful tools for evaluating the critical role of NO in cardiovascular physiology and therapeutics. These NO donors constitute two broad classes of compounds, those releasing NO and those requiring enzymatic metabolism to generate NO.

In vitro: SE 175 was identified as an organic nitrate donor of the same class as nitroglycerin, which acted as NO-donors following reductive transformation of the nitrate group to nitric oxide. SE 175 and other nitroxyacylated thiosalicylates were developed in an effort to facilitate such reductive process and accelerate the release of NO. SE 175 was found to be stable in buffer or saline solution. In addition, SE 175 was able to stimulate endothelial soluble guanylate cyclase and induce aortic vasorelaxation with an EC50 of 20 μM, which was intermediate in potency between isosorbide dinitrate and nitroglycerine [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Endres, S. ,Hacker, A.,Noack, E., et al. NO-donors, Part 3: Nitrooxyacylated thiosalicylates and salicylates-synthesis and biological activities. European Journal of Medicinal Chemistry 34, 895-901 (1999).

Chemical Properties

Cas No. 258278-64-7 SDF
化学名 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid, methyl ester
Canonical SMILES COC(=O)c1ccccc1SC(=O)c1ccc(CO[N](=O)O)cc1
分子式 C16H13NO6S 分子量 347.3
溶解度 ≤11mg/ml in ethanol;35mg/ml in DMSO;50mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.8794 mL 14.3968 mL 28.7936 mL
5 mM 0.5759 mL 2.8794 mL 5.7587 mL
10 mM 0.2879 mL 1.4397 mL 2.8794 mL
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