SAINT C-18
(Synonyms: SAINT-2,SAINT-7,SAINT-18,Synthetic Amphiphile INTeraction C-18) 目录号 : GC91556SAINT C-18 is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules.
Cas No.:187587-97-9
Sample solution is provided at 25 µL, 10mM.
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SAINT C-18 is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules.1,2,3,4 Complexes of SAINT C-18 with plasmid DNA encoding pigment epithelium-derived factor (PEDF) inhibit corneal neovascularization induced by complexes of SAINT C-18 with plasmid DNA encoding FGF2, also known as basic FGF, in rats.[2]
References:
[1].van der Woude, I., Wagenaar, A., Meekel, A.A.P., et al.Novel pyridinium surfactants for efficient, nontoxic in vitro gene deliveryProc. Natl. Acad. Sci. USA94(4)1160-1165(1997).
[2].Kuo, C.-N., Yang, L.-C., Yang, C.-T., et al.Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesisExp. Eye Res.89(5)678-685(2009).
[3].van der Gun, B.T.F., Monami, A., Laarmann, S., et al.Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2J. Control Release123(3)228-238(2007).
[4].Adrian, J.E., Morselt, H.W., Süss, R., et al.Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cellsJ. Control Release144(3)341-349(2010).
| Cas No. | 187587-97-9 | SDF | Download SDF |
| 别名 | SAINT-2,SAINT-7,SAINT-18,Synthetic Amphiphile INTeraction C-18 | ||
| 分子式 | C43H78N•Cl | 分子量 | 644.5 |
| 溶解度 | Acetonitrile: Slightly soluble,Chloroform: Soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5516 mL | 7.758 mL | 15.5159 mL |
| 5 mM | 0.3103 mL | 1.5516 mL | 3.1032 mL |
| 10 mM | 0.1552 mL | 0.7758 mL | 1.5516 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet