(S)-alpha-Fluoromethylhistidine HCl

α-Fluoromethylhistidine dihydrochloride is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase, demonstrating significant potential in studying histidine metabolism and drug metabolism processes. α-Fluoromethylhistidine dihydrochloride offers an effective approach to inhibit enzymes involved in these metabolic pathways. α-Fluoromethylhistidine dihydrochloride has implications for drug development by revealing off-target effects that may influence physiological drug metabolism and elimination mechanisms.

References:
[1]. Efficient synthesis of α-fluoromethylhistidine di-hydrochloride and demonstration of its efficacy as a glutathione S-transferase inhibitor.

α-Fluoromethylhistidine dihydrochloride 是组氨酸脱羧酶 (HDC) 和谷胱甘肽 S-转移酶的强效不可逆抑制剂，在研究组氨酸代谢和化合物代谢过程方面具有巨大潜力。α-Fluoromethylhistidine dihydrochloride 提供了一种抑制参与这些代谢途径的酶的有效方法。α-Fluoromethylhistidine dihydrochloride 通过揭示可能影响生理化合物代谢和消除机制的脱靶效应，对化合物开发具有重要意义。