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RO2959 hydrochloride Sale

目录号 : GC60327

RO2959hydrochloride是一种有效的选择性CRAC通道抑制剂,IC50为402nM。RO2959hydrochloride是由Orai1/Stim1通道介导的钙存储进入(SOCE)的有效阻滞剂,IC50为25nM。RO2959hydrochloride还是人IL-2产生的有效抑制剂,有效阻断T细胞受体触发的基因表达和T细胞功能途径。

RO2959 hydrochloride Chemical Structure

Cas No.:1219927-22-6

规格 价格 库存 购买数量
5 mg
¥3,150.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2].

RO2959 inhibits Orai1 and Orai3 with IC50 values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC50 value of 265 nM[1].RO2959 is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction)[1].

[1]. Gang Chen, et al. Characterization of a Novel CRAC Inhibitor That Potently Blocks Human T Cell Activation and Effector Functions. Mol Immunol. 2013 Jul;54(3-4):355-67. [2]. Changbo Zheng, et al. Gastrodin Inhibits Store-Operated Ca 2+ Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol. 2017 Apr 25;8:222.

Chemical Properties

Cas No. 1219927-22-6 SDF
Canonical SMILES O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[xHCl]
分子式 C21H19F2N5OS.xHCl 分子量
溶解度 储存条件 Store at -20°C
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