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Resistomycin Sale

(Synonyms: 抗霉素,Antibiotic A-3733A,Heliomycin) 目录号 : GC13832

A natural antibiotic

Resistomycin Chemical Structure

Cas No.:20004-62-0

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1mg
¥2,570.00
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5mg
¥8,962.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Resistomycin is a natural antibiotic.

Resistomycin is a natural antibiotic produced by several actinobacteriae, such as Streptomyces.

In vitro: Resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of Streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of Hypericum perforatum L. as modulators for apoptosis. In human megakaryoblastic leukemia CMK-7 cells, resistomycin could inhibit apoptosis induced by actinomycin D (AD) with or without acceleration by colcemid (CL), IC50 for inhibition against AD-induced apoptosis was about 0.5 μM and IC50 for inhibition against AD plus CL-induced apoptosis was about 1 μM. CL alone induced weak apoptosis in cells, which could be enhanced by resistomycin. Moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. In addition, PKC in CMK-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Shiono, Y. ,Shiono, N.,Seo, S., et al. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z. Naturforsch. C. 57(9-10), 923-929 (2002).

Chemical Properties

Cas No. 20004-62-0 SDF
别名 抗霉素,Antibiotic A-3733A,Heliomycin
化学名 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione
Canonical SMILES O=C1C(C)(C)C2=C3C4=C(C(O)=CC(C)=C4C(O)=C2)C(C5=C(O)C=C(O)C1=C53)=O
分子式 C22H16O6 分子量 376.4
溶解度 Soluble in DMSO;dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6567 mL 13.2837 mL 26.5675 mL
5 mM 0.5313 mL 2.6567 mL 5.3135 mL
10 mM 0.2657 mL 1.3284 mL 2.6567 mL
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