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NAE(NEDD8 活化酶)

NAE (NEDD8-activating enzyme) catalyzes the initial step of the neddylation signaling that regulates CRLs (cullin-ring ubiquitin ligases) activities. Its downstream effect is linked to cancer cell growth and survival.

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  2. GC15086 MLN4924 MLN4924 (MLN4924) 是一种有效的选择性 NEDD8 激活酶 (NAE) 抑制剂,IC50 为 4.7 nM。
  3. GC12175 MLN4924 HCl salt MLN4924 HCl salt (MLN4924 hydrochloride) 是一种有效的选择性 NEDD8 活化酶 (NAE) 抑制剂,IC50 为 4.7 nM。

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