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Nampt (nicotinamide phosphoribosyltransferase) catalyzes the nicotinamide condensation with 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide during the nicotinamide adenine dinucleotide biosynthesis. It is involved in the metabolism, stress response and aging.

  1. Cat.No. 产品名称 Information
  2. GC16709 CB 300919 CB 300919 是一种基于喹唑啉的抗肿瘤剂,在 CH1 人类卵巢肿瘤异种移植物中具有高活性。 CB 300919 在人类 CH1 卵巢肿瘤异种移植物中的持续暴露(96 小时)生长抑制 IC50 值为 2 nM。
  3. GC15207 CB30865 CB30865 (ZM 242421) 是一种烟酰胺磷酸核糖基转移酶 (Nampt) 抑制剂,具有强细胞毒性。 CB30865 对多种人类肿瘤细胞系非常有效(IC50 值在 1-10 nM 范围内)。
  4. GC14308 FK866 (APO866) Inhibitor of nicotinamide phosphoribosyltransferase
  5. GC14815 GMX1778 (CHS828) A pyridyl cyanoguanidine anti-tumor agent
  6. GC16041 GNE-617 A potent Nampt inhibitor
  7. GC15967 GNE-617 hydrochloride A potent Nampt inhibitor
  8. GC41308 GPP 78 Inhibitor of Nampt
  9. GC14615 KPT-9274 Orally acitve allosteric inhibitor of PAK4
  10. GC36429 LB-60-OF61
  11. GC32818 Nampt-IN-1 (LSN3154567) A potent Nampt inhibitor
  12. GC36690 Nampt-IN-3
  13. GC62476 Nampt-IN-5
  14. GC67797 NAT
  15. GC14692 P7C3 A proneurogenic and neuroprotective compound
  16. GC37602 SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.
  17. GC17096 STF-118804 A Nampt inhibitor
  18. GC61622 Teglarinad chloride

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