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IMPDH (inosine-5′-monophosphate dehydrogenase) catalyzes the initial rate-limiting step in the de novo guanine nucleotides synthesis. It is important for DNA/RNA synthesis, cell growth and malignant development etc.

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  2. GC12301 Mizoribine Mizoribine (NSC 289637) 抑制?HCV?RNA 复制,具有抗 HCV 活性,IC50?约为 100 μM。Mizoribine 是一种免疫抑制剂。Mizoribine 抑制?IMPDH。Mizoribine 抑制?SARS-CoV?复制,对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50?分别为 3.5 μg/mL 和 16 μg/mL。

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