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Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.

Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.

  1. Cat.No. 产品名称 Information
  2. GC15572 (+)-trans-C75 An enantiomer of a FASN inhibitor
  3. GC16184 (-)-trans-C75 An enantiomer of a FASN inhibitor
  4. GN10632 Betulin An inhibitor of SREBP-driven cholesterol biosynthesis
  5. GC34065 C75 An anorexigenic inhibitor of fatty acid synthase (FASN)
  6. GC14025 Cerulenin A fungal metabolite with diverse biological activities
  7. GC38221 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
  8. GC38535 Dihydrocurcumin
  9. GP26019 FAS Human, Sf9 FAS Human Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 156 amino acids (26-173 aa) and having a molecular mass of 17
  10. GC31406 FAS-IN-1
  11. GC34311 FAS-IN-1 Tosylate
  12. GC33398 FASN inhibitor 1
  13. GC34584 FASN-IN-1
  14. GC36030 FASN-IN-2 A FASN inhibitor
  15. GC36031 Fatostatin

    An inhibitor of SREBP activation

  16. GC18121 Fatostatin A hydrobromide An inhibitor of SREBP activation
  17. GC31323 FGH10019
  18. GC33374 HS79
  19. GC33346 HS80
  20. GC14316 ML-356 A selective inhibitor of FASN-TE
  21. GC36736 Nicodicosapent
  22. GC17318 Orlistat

    Orlistat is an irreversible inhibitor of lipases in the pancreas and stomach.

  23. GN10392 Praeruptorin B Praeruptorin B 是甾醇调节元件结合蛋白 (SREBPs) 的抑制剂。
  24. GC38839 Pseudoprotodioscin A steroidal saponin with diverse biological activities
  25. GC38710 TVB-3166 A FASN inhibitor
  26. GC15091 UCM05 A fatty acid synthase inhibitor

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