FAS
Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.
Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.
- Cat.No. 产品名称 Information
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GC15572
(+)-trans-C75
An enantiomer of a FASN inhibitor
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GC16184
(-)-trans-C75
An enantiomer of a FASN inhibitor
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GN10632
Betulin
An inhibitor of SREBP-driven cholesterol biosynthesis
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GC34065
C75
An anorexigenic inhibitor of fatty acid synthase (FASN)
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GC14025
Cerulenin
A fungal metabolite with diverse biological activities
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GC38221
Desoxyrhaponticin
Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
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GC38535
Dihydrocurcumin
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GP26019
FAS Human, Sf9
FAS Human Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 156 amino acids (26-173 aa) and having a molecular mass of 17
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GC31406
FAS-IN-1
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GC34311
FAS-IN-1 Tosylate
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GC33398
FASN inhibitor 1
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GC34584
FASN-IN-1
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GC36030
FASN-IN-2
A FASN inhibitor
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GC36031
Fatostatin
An inhibitor of SREBP activation
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GC18121
Fatostatin A hydrobromide
An inhibitor of SREBP activation
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GC31323
FGH10019
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GC33374
HS79
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GC33346
HS80
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GC14316
ML-356
A selective inhibitor of FASN-TE
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GC36736
Nicodicosapent
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GC17318
Orlistat
Orlistat is an irreversible inhibitor of lipases in the pancreas and stomach.
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GN10392
Praeruptorin B
Praeruptorin B 是甾醇调节元件结合蛋白 (SREBPs) 的抑制剂。
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GC38839
Pseudoprotodioscin
A steroidal saponin with diverse biological activities
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GC38710
TVB-3166
A FASN inhibitor
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GC15091
UCM05
A fatty acid synthase inhibitor